3PKJ
Human SIRT6 crystal structure in complex with 2'-N-Acetyl ADP ribose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | NAD-dependent deacetylase sirtuin-6 | polymer | 355 | 39106.7 | 6 | UniProt (Q8N6T7) Pfam (PF02146) | Homo sapiens (human) | SIR2-like protein 6 |
| 2 | AB, G, LA, M, RA... (F, A, D, B, E...) | [(2R,3S,4R,5R)-4-(acetylamino)-3,5-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate | non-polymer | 600.4 | 6 | Chemie (A2N) PubChem (16742554) PubChem (23636413) PubChem (24750905) PubChem (58971933) PubChem (58971938) PubChem (89332983) PubChem (89332969) PubChem (89333795) PubChem (91586434) | |||
| 3 | BB, H, MA, N, SA... (F, A, D, B, E...) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | CB, DB, EB, I, NA... (F, A, D, B, E...) | SULFATE ION | non-polymer | 96.1 | 12 | Chemie (SO4) | |||
| 5 | AA, BA, CA, DA, EA... (C, F, A, D, B...) | UNKNOWN ATOM OR ION | non-polymer | 35 | Chemie (UNX) | ||||
| 6 | NB, OB, PB, QB, RB... (A, B, C, D, E...) | water | water | 18.0 | 486 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 0 - 353 (UniProt: Q8N6T7)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Glu 265 | Lys 267 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 234640.2 | |
| Non-Polymers* | Number of molecules | 59 |
| Total formula weight | 5147.4 | |
| All* | Total formula weight | 239787.7 |
