4R3B

Crystal structure of SHV-1 b-lactamase in complex with 6b-(hydroxymethyl)penicillanic acid sulfone PSR-283A

Summary for 4R3B

• Entry DOI: 10.2210/pdb4r3b/pdb
• Related: 2H4S 4FH4
• Descriptor: Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, (2S)-3-[bis(oxidanylidene)-$l^{5}-sulfanyl]-2-[[2-(hydroxymethyl)-3-oxidanyl-propyl]amino]-3-methyl-butanoic acid, ... (4 entities in total)
• Functional Keywords: class a beta-lactamase, hydrolase, inactivate b-lactam antibiotics
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 30192.53

Authors

Rodkey, E.A.,van den Akker, F. (deposition date: 2014-08-14, release date: 2015-01-21, Last modification date: 2015-02-11)

• Primary citation: Che, T.,Rodkey, E.A.,Bethel, C.R.,Shanmugam, S.,Ding, Z.,Pusztai-Carey, M.,Nottingham, M.,Chai, W.,Buynak, J.D.,Bonomo, R.A.,van den Akker, F.,Carey, P.R.; Detecting a Quasi-stable Imine Species on the Reaction Pathway of SHV-1 beta-Lactamase and 6 beta-(Hydroxymethyl)penicillanic Acid Sulfone.; Biochemistry, 54:734-743, 2015; PubMed: 25536850; DOI: 10.1021/bi501197t

Experimental method

X-RAY DIFFRACTION (1.366 Å)