4R3B

Crystal structure of SHV-1 b-lactamase in complex with 6b-(hydroxymethyl)penicillanic acid sulfone PSR-283A

Summary for 4R3B

Entry DOI	10.2210/pdb4r3b/pdb
Related	2H4S 4FH4
Descriptor	Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, N-[(1E)-2-formyl-3-hydroxyprop-1-en-1-yl]-3-[(S)-sulfino]-D-valine, ... (4 entities in total)
Functional Keywords	class a beta-lactamase, hydrolase, inactivate b-lactam antibiotics
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	30189.50
Authors	Rodkey, E.A.,van den Akker, F. (deposition date: 2014-08-14, release date: 2015-01-21, Last modification date: 2024-05-15)
Primary citation	Che, T.,Rodkey, E.A.,Bethel, C.R.,Shanmugam, S.,Ding, Z.,Pusztai-Carey, M.,Nottingham, M.,Chai, W.,Buynak, J.D.,Bonomo, R.A.,van den Akker, F.,Carey, P.R. Detecting a Quasi-stable Imine Species on the Reaction Pathway of SHV-1 beta-Lactamase and 6 beta-(Hydroxymethyl)penicillanic Acid Sulfone. Biochemistry, 54:734-743, 2015 Cited by PubMed: 25536850 DOI: 10.1021/bi501197t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.366 Å)

Structure validation