6WKN

PL-bound rat TRPV2 in nanodiscs

Summary for 6WKN

Entry DOI	10.2210/pdb6wkn/pdb
EMDB information	21705
Descriptor	Transient receptor potential cation channel subfamily V member 2, piperlongumine (2 entities in total)
Functional Keywords	trp channel, trpv2, piperlongumine, ion channel, transport protein
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	4
Total formula weight	348464.91
Authors	Pumroy, R.P.,Moiseenkova-Bell, V.Y. (deposition date: 2020-04-16, release date: 2021-04-21, Last modification date: 2024-03-06)
Primary citation	Conde, J.,Pumroy, R.A.,Baker, C.,Rodrigues, T.,Guerreiro, A.,Sousa, B.B.,Marques, M.C.,de Almeida, B.P.,Lee, S.,Leites, E.P.,Picard, D.,Samanta, A.,Vaz, S.H.,Sieglitz, F.,Langini, M.,Remke, M.,Roque, R.,Weiss, T.,Weller, M.,Liu, Y.,Han, S.,Corzana, F.,Morais, V.A.,Faria, C.C.,Carvalho, T.,Filippakopoulos, P.,Snijder, B.,Barbosa-Morais, N.L.,Moiseenkova-Bell, V.Y.,Bernardes, G.J.L. Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression. Acs Cent.Sci., 7:868-881, 2021 Cited by PubMed: 34079902 DOI: 10.1021/acscentsci.1c00070 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.46 Å)

Structure validation