8UK5

Crystal structure of the bromodomain of human ATAD2B in complex with histone H4S1(ph)K5ac

Summary for 8UK5

Entry DOI	10.2210/pdb8uk5/pdb
Descriptor	ATPase family AAA domain-containing protein 2B, Histone H4S1(ph)K5ac (3 entities in total)
Functional Keywords	bromodomain, epigenetics, chromatin reader domain, protein binding, histone acetylation, peptide binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	17166.50
Authors	Montgomery, C.,Phillips, M.,Nix, J.C.,Glass, K.C. (deposition date: 2023-10-12, release date: 2024-06-05)
Primary citation	Phillips, M.,Malone, K.L.,Boyle, B.W.,Montgomery, C.,Kressy, I.A.,Joseph, F.M.,Bright, K.M.,Boyson, S.P.,Chang, S.,Nix, J.C.,Young, N.L.,Jeffers, V.,Frietze, S.,Glass, K.C. Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains. J.Med.Chem., 67:8186-8200, 2024 Cited by PubMed: 38733345 DOI: 10.1021/acs.jmedchem.4c00210 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation