7OTV
 
 | | DNA-PKcs in complex with wortmannin | | 分子名称: | (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE, DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs | | 著者 | Liang, S, Thomas, S.E, Blundell, T.L. | | 登録日 | 2021-06-10 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-09 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs.
Nature, 601, 2022
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7OTM
 | | Cryo-EM structure of DNA-PKcs in complex with NU7441 | | 分子名称: | 8-(dibenzo[b,d]thiophen-4-yl)-2-(morpholin-4-yl)-4H-chromen-4-one, DNA-dependent protein kinase catalytic subunit,DNA-PKcs | | 著者 | Liang, S, Thomas, S.E, Blundell, T.L. | | 登録日 | 2021-06-10 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-09 | | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | | 主引用文献 | Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs.
Nature, 601, 2022
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7OTW
 | | DNA-PKcs in complex with AZD7648 | | 分子名称: | 7-methyl-2-[(7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(oxan-4-yl)purin-8-one, DNA-dependent protein kinase catalytic subunit,DNA-PKcs | | 著者 | Liang, S, Thomas, S.E, Blundell, T.L. | | 登録日 | 2021-06-10 | | 公開日 | 2022-01-12 | | 最終更新日 | 2022-02-09 | | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | | 主引用文献 | Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs.
Nature, 601, 2022
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7PC0
 | | GABA-A receptor bound by a-Cobratoxin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-cobratoxin, ... | | 著者 | Kasaragod, V.B, Miller, P.S. | | 登録日 | 2021-08-03 | | 公開日 | 2022-02-09 | | 最終更新日 | 2022-03-02 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors.
Nature, 602, 2022
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7PBD
 | | a1b3 GABA-A receptor + GABA | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | | 著者 | Miller, P.S, Kasaragod, V.B. | | 登録日 | 2021-08-02 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors.
Nature, 602, 2022
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7PBZ
 | | a1b3 GABA-A receptor + GABA + Zn2+ | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DECANE, ... | | 著者 | Miller, P.S, Kasaragod, V.B. | | 登録日 | 2021-08-03 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | | 主引用文献 | Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors.
Nature, 602, 2022
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8BHR
 | | GABA-A receptor a5 homomer - a5V3 - RO7015738 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-[[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy]-~{N}-[(2~{S})-1-oxidanylpentan-2-yl]pyridine-3-carboxamide, Gamma-aminobutyric acid receptor subunit alpha-5 | | 著者 | Miller, P.S, Malinauskas, T.M, Kasaragod, V.B. | | 登録日 | 2022-10-31 | | 公開日 | 2023-11-01 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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8BHQ
 | | GABA-A receptor a5 homomer - a5V3 - RO7172670 | | 分子名称: | 2-[[5-methyl-3-(6-methylpyridazin-3-yl)-1,2-oxazol-4-yl]methyl]-5-(5-oxa-2-azaspiro[3.5]nonan-2-yl)pyridazin-3-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5 | | 著者 | Miller, P.S, Malinauskas, T.M, Hardwick, S.W, Kasaragod, V.B. | | 登録日 | 2022-10-31 | | 公開日 | 2023-11-01 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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8BGI
 | | GABA-A receptor a5 homomer - a5V1 - Flumazenil | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-5, Pregnanolone, ... | | 著者 | Miller, P.S, Malinauskas, T.M, Omari, K.E, Aricescu, A.R. | | 登録日 | 2022-10-27 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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8BHG
 | | GABA-A receptor a5 heteromer - a5V2 - Bretazenil | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bretazenil, DECYL-BETA-D-MALTOPYRANOSIDE, ... | | 著者 | Miller, P.S, Malinauskas, T.M, Omari, K.E, Aricescu, A.R. | | 登録日 | 2022-10-31 | | 公開日 | 2023-11-15 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | The molecular basis of drug selectivity for alpha 5 subunit-containing GABA A receptors.
Nat.Struct.Mol.Biol., 30, 2023
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7Z6O
 | | X-Ray studies of Ku70/80 reveal the binding site for IP6 | | 分子名称: | DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Varela, P.F, Charbonnier, J.B. | | 登録日 | 2022-03-14 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res., 51, 2023
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7ZT6
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8ASC
 | | Ku70/80 binds to the Ku-binding motif of PAXX | | 分子名称: | DNA (5'-D(P*CP*GP*GP*AP*TP*CP*GP*AP*GP*GP*GP*CP*CP*CP*GP*AP*TP*AP*T)-3'), DNA (5'-D(P*GP*GP*GP*CP*CP*CP*TP*CP*GP*AP*TP*CP*CP*G)-3'), Protein PAXX, ... | | 著者 | Seif El Dahan, M, Ropars, V, Charbonnier, J.B. | | 登録日 | 2022-08-19 | | 公開日 | 2023-06-21 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
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8BOT
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8BR2
 | | CryoEM structure of the post-synaptic RAD51 nucleoprotein filament in the presence of ATP and Ca2+ | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*GP*CP*GP*AP*GP*CP*TP*CP*GP*AP*TP*GP*CP*AP*CP*CP*TP*CP*CP*A)-3'), ... | | 著者 | Appleby, R, Bollschweiler, D, Pellegrini, L. | | 登録日 | 2022-11-22 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | A metal ion-dependent mechanism of RAD51 nucleoprotein filament disassembly.
Iscience, 26, 2023
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8BSC
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8BQ2
 | | CryoEM structure of the pre-synaptic RAD51 nucleoprotein filament in the presence of ATP and Ca2+ | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (30-MER), ... | | 著者 | Appleby, R, Bollschweiler, D, Pellegrini, L. | | 登録日 | 2022-11-18 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | A metal ion-dependent mechanism of RAD51 nucleoprotein filament disassembly.
Iscience, 26, 2023
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8BHY
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8BHV
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8BH3
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5CP9
 | | The structure of the NK1 fragment of HGF/SF complexed with MB605 | | 分子名称: | 1,2-ETHANEDIOL, 3-(furan-2-yl)propanoic acid, Hepatocyte growth factor | | 著者 | Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. | | 登録日 | 2015-07-21 | | 公開日 | 2015-08-12 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
Chem Sci, 6, 2015
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5COE
 | | The structure of the NK1 fragment of HGF/SF complexed with HEPES | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Hepatocyte growth factor | | 著者 | Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Ascher, D.B, Chirgadze, D.Y, Blundell, T.L, Gherardi, E. | | 登録日 | 2015-07-20 | | 公開日 | 2015-08-12 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
Chem Sci, 6, 2015
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5CSQ
 | | The structure of the NK1 fragment of HGF/SF complexed with MOPS | | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Hepatocyte growth factor | | 著者 | Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. | | 登録日 | 2015-07-23 | | 公開日 | 2015-08-12 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
Chem Sci, 6, 2015
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5CS9
 | | The structure of the NK1 fragment of HGF/SF complexed with MES | | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Hepatocyte growth factor | | 著者 | Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. | | 登録日 | 2015-07-23 | | 公開日 | 2015-08-12 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
Chem Sci, 6, 2015
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5CT1
 | | The structure of the NK1 fragment of HGF/SF complexed with CHES | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Hepatocyte growth factor | | 著者 | Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E. | | 登録日 | 2015-07-23 | | 公開日 | 2015-08-12 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
Chem Sci, 6, 2015
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