5COE

The structure of the NK1 fragment of HGF/SF complexed with HEPES

Summary for 5COE

Entry DOI	10.2210/pdb5coe/pdb
Related	1BHT 1NK1
Descriptor	Hepatocyte growth factor, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID (3 entities in total)
Functional Keywords	hgf/sf, fragment based discovery, growth factor, nk1 fragment, cell cycle, hormone
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	42582.85
Authors	Sigurdardottir, A.G.,Winter, A.,Sobkowicz, A.,Fragai, M.,Ascher, D.B.,Chirgadze, D.Y.,Blundell, T.L.,Gherardi, E. (deposition date: 2015-07-20, release date: 2015-08-12, Last modification date: 2024-01-10)
Primary citation	Sigurdardottir, A.G.,Winter, A.,Sobkowicz, A.,Fragai, M.,Chirgadze, D.,Ascher, D.B.,Blundell, T.L.,Gherardi, E. Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chem Sci, 6:6147-6157, 2015 Cited by PubMed: 30090230 DOI: 10.1039/c5sc02155c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.18 Å)

Structure validation