7OTV

DNA-PKcs in complex with wortmannin

Summary for 7OTV

Entry DOI	10.2210/pdb7otv/pdb
EMDB information	13067
Descriptor	DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs, (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE (2 entities in total)
Functional Keywords	complex, inhibitor, dna repair, dna binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	471803.84
Authors	Liang, S.,Thomas, S.E.,Blundell, T.L. (deposition date: 2021-06-10, release date: 2022-01-12, Last modification date: 2022-02-09)
Primary citation	Liang, S.,Thomas, S.E.,Chaplin, A.K.,Hardwick, S.W.,Chirgadze, D.Y.,Blundell, T.L. Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs. Nature, 601:643-648, 2022 Cited by PubMed: 34987222 DOI: 10.1038/s41586-021-04274-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.24 Å)

Structure validation