3RIJ
 
 | | Epitope backbone grafting by computational design for improved presentation of linear epitopes on scaffold proteins | | 分子名称: | GLYCEROL, SC_2cx5 | | 著者 | Azoitei, M.L, Ban, Y.A, Julien, J.P, Bryson, S, Schroeter, A, Kalyuzhniy, O, Porter, J.R, Adachi, Y, Baker, D, Szabo, E, Pai, E.F, Schief, W.R. | | 登録日 | 2011-04-13 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
J.Mol.Biol., 415, 2012
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3RHU
 | | Epitope backbone grafting by computational design for improved presentation of linear epitopes on scaffold proteins | | 分子名称: | SC_1wnu | | 著者 | Azoitei, M.L, Ban, Y.A, Julien, J.P, Bryson, S, Schroeter, A, Kalyuzhniy, O, Porter, J.R, Adachi, Y, Baker, D, Szabo, E, Pai, E.F, Schief, W.R. | | 登録日 | 2011-04-12 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
J.Mol.Biol., 415, 2012
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3RI0
 | | Epitope backbone grafting by computational design for improved presentation of linear epitopes on scaffold proteins | | 分子名称: | BB_2cx5_001, GLYCEROL, SULFATE ION | | 著者 | Azoitei, M.L, Ban, Y.A, Julien, J.P, Bryson, S, Schroeter, A, Kalyuzhniy, O, Porter, J.R, Adachi, Y, Baker, D, Szabo, E, Pai, E.F, Schief, W.R. | | 登録日 | 2011-04-12 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
J.Mol.Biol., 415, 2012
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3RFN
 | | Epitope backbone grafting by computational design for improved presentation of linear epitopes on scaffold proteins | | 分子名称: | BB_1wnu_001, ZINC ION | | 著者 | Azoitei, M.L, Ban, Y.A, Julien, J.P, Bryson, S, Schroeter, A, Kalyuzhniy, O, Porter, J.R, Adachi, Y, Baker, D, Szabo, E, Pai, E.F, Schief, W.R. | | 登録日 | 2011-04-06 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
J.Mol.Biol., 415, 2012
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6AZX
 | | Crystal structure of the neutralizing anti-circumsporozoite protein 663 antibody | | 分子名称: | 663 antibody, heavy chain, light chain | | 著者 | Scally, S.W, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | | 登録日 | 2017-09-13 | | 公開日 | 2017-12-13 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.
Immunity, 47, 2017
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6B0W
 | | Crystal structure of the anti-circumsporozoite protein 1710 antibody | | 分子名称: | 1710 antibody, heavy chain, light chain, ... | | 著者 | Scally, S.W, Murugan, R, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | | 登録日 | 2017-09-15 | | 公開日 | 2017-11-08 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection.
J. Exp. Med., 215, 2018
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6AZZ
 | | Crystal structure of Pfs25 in complex with the transmission blocking antibody 1190 | | 分子名称: | 1190 antibody, heavy chain, light chain, ... | | 著者 | Scally, S.W, McLeod, B, Bosch, A, King, C.R, Julien, J.P. | | 登録日 | 2017-09-13 | | 公開日 | 2017-11-08 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nat Commun, 8, 2017
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6B0E
 | | Crystal structure of Pfs25 in complex with the transmission blocking antibody 1260 | | 分子名称: | 1260 antibody, heavy chain, light chain, ... | | 著者 | Scally, S.W, McLeod, B, Bosch, A, King, C.R, Julien, J.P. | | 登録日 | 2017-09-14 | | 公開日 | 2017-11-15 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nat Commun, 8, 2017
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6AZM
 | | Crystal structure of the 580 germline antibody bound to circumsporozoite protein NANP 5-mer | | 分子名称: | 580 germline antibody, heavy chain, light chain, ... | | 著者 | Scally, S.W, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | | 登録日 | 2017-09-11 | | 公開日 | 2017-12-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.
Immunity, 47, 2017
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6B0G
 | | Crystal structure of Pfs25 in complex with the transmission blocking antibody 1245 | | 分子名称: | 1245 Antibody, Heavy Chain, Light Chain, ... | | 著者 | McLeod, B, Scally, S.W, Bosch, A, King, C.R, Julien, J.P. | | 登録日 | 2017-09-14 | | 公開日 | 2017-11-08 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nat Commun, 8, 2017
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6B0S
 | | Crystal structure of circumsporozoite protein aTSR domain in complex with 1710 antibody | | 分子名称: | 1710 antibody, heavy chain, light chain, ... | | 著者 | Scally, S.W, Murugan, R, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | | 登録日 | 2017-09-15 | | 公開日 | 2017-11-08 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection.
J. Exp. Med., 215, 2018
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6B0A
 | | Crystal structure of Pfs25 in complex with the transmission blocking antibody 1269 | | 分子名称: | 1269 antibody, heavy chain, light chain, ... | | 著者 | Scally, S.W, McLeod, B, Bosch, A, King, C.R, Julien, J.P. | | 登録日 | 2017-09-14 | | 公開日 | 2017-11-15 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nat Commun, 8, 2017
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6B08
 | | Crystal structure of Pfs25 in complex with the transmission blocking antibody 1276 | | 分子名称: | 1276 antibody, heavy chain, light chain, ... | | 著者 | Scally, S.W, McLeod, B, Bosch, A, King, C.R, Julien, J.P. | | 登録日 | 2017-09-14 | | 公開日 | 2017-11-15 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nat Commun, 8, 2017
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6B0H
 | | Crystal structure of Pfs25 in complex with the transmission blocking antibody 1262 | | 分子名称: | 1,2-ETHANEDIOL, 1262 antibody, heavy chain, ... | | 著者 | McLeod, B, Scally, S.W, Bosch, A, King, C.R, Julien, J.P. | | 登録日 | 2017-09-14 | | 公開日 | 2017-11-15 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nat Commun, 8, 2017
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6D0X
 | | Crystal structure of chimeric H.2140 / K.1210 Fab in complex with circumsporozoite protein NANP3 | | 分子名称: | 1210 Antibody, light chain, 2140 Antibody, ... | | 著者 | Scally, S.W, Bosch, A, Imkeller, K, Wardemann, H, Julien, J.P. | | 登録日 | 2018-04-11 | | 公開日 | 2018-06-13 | | 最終更新日 | 2018-07-04 | | 実験手法 | X-RAY DIFFRACTION (1.849 Å) | | 主引用文献 | Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.
Science, 360, 2018
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6D01
 | | Crystal structure of 1210 Fab in complex with circumsporozoite protein NANP5 | | 分子名称: | 1,2-ETHANEDIOL, 1210 Antibody, Light chain, ... | | 著者 | Scally, S.W, Bosch, A, Imkeller, K, Wardemann, H, Julien, J.P. | | 登録日 | 2018-04-09 | | 公開日 | 2018-06-13 | | 最終更新日 | 2018-07-04 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.
Science, 360, 2018
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6D11
 | | Crystal structure of 1450 Fab in complex with circumsporozoite protein NANP5 | | 分子名称: | 1450 Antibody, Heavy chain, Light chain, ... | | 著者 | Scally, S.W, Bosch, A, Imkeller, K, Wardemann, H, Julien, J.P. | | 登録日 | 2018-04-11 | | 公開日 | 2018-06-13 | | 最終更新日 | 2018-07-04 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.
Science, 360, 2018
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6CCB
 | | Crystal structure of 253-11 SOSIP trimer in complex with 10-1074 Fab | | 分子名称: | 10-1074 FAB heavy chain, 10-1074 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Moyo, T, Ereno-Orbea, J, Dorfman, J, Julien, J.P. | | 登録日 | 2018-02-06 | | 公開日 | 2018-04-04 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (6.5 Å) | | 主引用文献 | Molecular Basis of Unusually High Neutralization Resistance in Tier 3 HIV-1 Strain 253-11.
J. Virol., 92, 2018
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4NCO
 | | Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIP gp120, BG505 SOSIP gp41, ... | | 著者 | Julien, J.-P, Stanfield, R.L, Lyumkis, D, Ward, A.B, Wilson, I.A. | | 登録日 | 2013-10-24 | | 公開日 | 2013-11-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (4.7 Å) | | 主引用文献 | Crystal structure of a soluble cleaved HIV-1 envelope trimer.
Science, 342, 2013
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4JY4
 | | Crystal structure of human Fab PGT121, a broadly reactive and potent HIV-1 neutralizing antibody | | 分子名称: | GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PGT121 heavy chain, ... | | 著者 | Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A. | | 登録日 | 2013-03-29 | | 公開日 | 2013-05-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.
Plos Pathog., 9, 2013
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4JY6
 | | Crystal structure of human Fab PGT123, a broadly reactive and potent HIV-1 neutralizing antibody | | 分子名称: | GLYCEROL, PGT123 heavy chain, PGT123 light chain, ... | | 著者 | Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A. | | 登録日 | 2013-03-29 | | 公開日 | 2013-05-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans.
Plos Pathog., 9, 2013
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4JY5
 | | Crystal structure of human Fab PGT122, a broadly reactive and potent HIV-1 neutralizing antibody | | 分子名称: | GLYCEROL, PGT122 heavy chain, PGT122 light chain | | 著者 | Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A. | | 登録日 | 2013-03-29 | | 公開日 | 2013-05-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.
Plos Pathog., 9, 2013
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3DRO
 | | Crystal structure of the HIV-1 Cross Neutralizing Antibody 2F5 in complex with gp41 Peptide ELLELDKWASLWN grown in ammonium sulfate | | 分子名称: | 2F5 Fab heavy chain, 2F5 Fab light chain, ELLELDKWASLWN gp41 peptide | | 著者 | Julien, J.-P, Bryson, S, Pai, E.F. | | 登録日 | 2008-07-11 | | 公開日 | 2008-07-29 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | | 主引用文献 | Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
J.Mol.Biol., 384, 2008
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2PR4
 | | Crystal Structure of Fab' from the HIV-1 Neutralizing Antibody 2F5 | | 分子名称: | nmAb 2F5 Fab' Heavy Chain, nmAb 2F5 Fab' light Chain | | 著者 | Bryson, S, Julien, J.-P, Pai, E.F. | | 登録日 | 2007-05-03 | | 公開日 | 2007-05-15 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
J.Mol.Biol., 384, 2008
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2P8P
 | | Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide LELDKWASLW[N-Ac] | | 分子名称: | gp41 peptide, nmAb 2F5, heavy chain, ... | | 著者 | Bryson, S, Julien, J.-P, Pai, E.F. | | 登録日 | 2007-03-22 | | 公開日 | 2007-05-15 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
J.Mol.Biol., 384, 2008
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