3RHU

Epitope backbone grafting by computational design for improved presentation of linear epitopes on scaffold proteins

Summary for 3RHU

• Entry DOI: 10.2210/pdb3rhu/pdb
• Related: 3RFN 3RI0 3RIJ
• Descriptor: SC_1wnu (1 entity in total)
• Functional Keywords: protein grafting, flexible backbone design, epitope-scaffold, hiv, immunogen design, de novo protein
• Biological source: Pyrococcus horikoshii; More
• Cellular location: Cytoplasm : O58307
• Total number of polymer chains: 2
• Total formula weight: 36371.96

Authors

Azoitei, M.L.,Ban, Y.A.,Julien, J.P.,Bryson, S.,Schroeter, A.,Kalyuzhniy, O.,Porter, J.R.,Adachi, Y.,Baker, D.,Szabo, E.,Pai, E.F.,Schief, W.R. (deposition date: 2011-04-12, release date: 2011-11-09, Last modification date: 2023-09-13)

• Primary citation: Azoitei, M.L.,Ban, Y.E.,Julien, J.P.,Bryson, S.,Schroeter, A.,Kalyuzhniy, O.,Porter, J.R.,Adachi, Y.,Baker, D.,Pai, E.F.,Schief, W.R.; Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.; J.Mol.Biol., 415:175-192, 2012; PubMed: 22061265; DOI: 10.1016/j.jmb.2011.10.003

Experimental method

X-RAY DIFFRACTION (2.8 Å)