3DRO

Crystal structure of the HIV-1 Cross Neutralizing Antibody 2F5 in complex with gp41 Peptide ELLELDKWASLWN grown in ammonium sulfate

Summary for 3DRO

• Entry DOI: 10.2210/pdb3dro/pdb
• Related: 2P8M 3DRQ 3DRT 3DRV
• Descriptor: 2F5 Fab light chain, 2F5 Fab heavy chain, ELLELDKWASLWN gp41 peptide (3 entities in total)
• Functional Keywords: hiv-1, gp41, 2f5, nmab, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Host cell membrane ; Single-pass type I membrane protein . Host endosome membrane ; Single-pass type I membrane protein . Virion membrane ; Single-pass type I membrane protein : Q5S532
• Total number of polymer chains: 3
• Total formula weight: 49967.10

Authors

Julien, J.-P.,Bryson, S.,Pai, E.F. (deposition date: 2008-07-11, release date: 2008-07-29, Last modification date: 2023-08-30)

• Primary citation: Julien, J.P.,Bryson, S.,Nieva, J.L.,Pai, E.F.; Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.; J.Mol.Biol., 384:377-392, 2008; PubMed: 18824005; DOI: 10.1016/j.jmb.2008.09.024

Experimental method

X-RAY DIFFRACTION (3.9 Å)