3DRT

Crystal structure of the HIV-1 broadly neutralizing antibody 2F5 in complex with the gp41 scrambledFP-MPER scrHyb3K construct GIGAFGLLGFLAAGSKK-Ahx-K656NEQELLELDKWASLWN671

Summary for 3DRT

Entry DOI	10.2210/pdb3drt/pdb
Related	2P8M 3D0L 3DRO 3DRQ 3DRV
Descriptor	2F5 Fab' light chain, 2F5 Fab' heavy chain, scrHyb3K construct, ... (4 entities in total)
Functional Keywords	hiv-1, gp41, 2f5, nmab, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	52263.78
Authors	Julien, J.-P.,Bryson, S.,de la Torre, B.G.,Andreu, D.,Nieva, J.L.,Pai, E.F. (deposition date: 2008-07-11, release date: 2009-06-23, Last modification date: 2023-11-15)
Primary citation	de la Arada, I.,Julien, J.P.,de la Torre, B.G.,Huarte, N.,Andreu, D.,Pai, E.F.,Arrondo, J.L.,Nieva, J.L. Structural constraints imposed by the conserved fusion peptide on the HIV-1 gp41 epitope recognized by the broadly neutralizing antibody 2F5. J.Phys.Chem.B, 113:13626-13637, 2009 Cited by PubMed: 19754136 DOI: 10.1021/jp905965h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation