4MSK
| Co-crystal structure of tankyrase 1 with compound 34 | 分子名称: | 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]propanamide, Tankyrase-1, ZINC ION | 著者 | Huang, X. | 登録日 | 2013-09-18 | 公開日 | 2013-12-25 | 最終更新日 | 2014-02-05 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors. J.Med.Chem., 56, 2013
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4MT9
| Co-crystal structure of tankyrase 1 with compound 49 | 分子名称: | N-[trans-4-(4-cyanophenoxy)cyclohexyl]-3-[(4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]propanamide, Tankyrase-1, ZINC ION | 著者 | Huang, X. | 登録日 | 2013-09-19 | 公開日 | 2013-12-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors. J.Med.Chem., 56, 2013
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4MSG
| Crystal structure of tankyrase 1 with compound 22 | 分子名称: | 3-[(4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-[trans-4-(5-phenyl-1,3,4-oxadiazol-2-yl)cyclohexyl]propanamide, Tankyrase-1, ZINC ION | 著者 | Huang, X. | 登録日 | 2013-09-18 | 公開日 | 2013-12-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors. J.Med.Chem., 56, 2013
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4QOC
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6UGL
| VqmA bound to DPO | 分子名称: | 3,5-dimethylpyrazin-2(1H)-one, Helix-turn-helix transcriptional regulator | 著者 | Paczkowski, J.E, Huang, X. | 登録日 | 2019-09-26 | 公開日 | 2020-01-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Mechanism underlying autoinducer recognition in theVibrio choleraeDPO-VqmA quorum-sensing pathway. J.Biol.Chem., 295, 2020
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3H5C
| X-Ray Structure of Protein Z-Protein Z Inhibitor Complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein Z-dependent protease inhibitor, Vitamin K-dependent protein Z, ... | 著者 | Dementiev, A.A, Huang, X, Olson, S.T, Gettins, P.G.W. | 登録日 | 2009-04-21 | 公開日 | 2010-04-28 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.26 Å) | 主引用文献 | Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa. J.Biol.Chem., 285, 2010
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4DVI
| Crystal structure of Tankyrase 1 with IWR2 | 分子名称: | 4-[(3aR,4S,7R,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(4-methylquinolin-8-yl)benzamide, Tankyrase-1, ZINC ION | 著者 | Huang, X. | 登録日 | 2012-02-23 | 公開日 | 2012-04-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Novel binding mode of a potent and selective tankyrase inhibitor. Plos One, 7, 2012
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3JZK
| crystal structure of MDM2 with chromenotriazolopyrimidine 1 | 分子名称: | (6R,7S)-6,7-bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine, E3 ubiquitin-protein ligase Mdm2 | 著者 | Huang, X. | 登録日 | 2009-09-23 | 公開日 | 2009-11-17 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J.Med.Chem., 52, 2009
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6CZS
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6CZK
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5CFB
| Crystal Structure of Human Glycine Receptor alpha-3 Bound to Strychnine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alpha-3,Glycine receptor subunit alpha-3, ... | 著者 | Shaffer, P.L, Huang, X, Chen, H. | 登録日 | 2015-07-08 | 公開日 | 2015-09-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.04 Å) | 主引用文献 | Crystal structure of human glycine receptor-alpha 3 bound to antagonist strychnine. Nature, 526, 2015
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3TJC
| Co-crystal structure of jak2 with thienopyridine 8 | 分子名称: | 4-amino-N-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 | 著者 | Huang, X. | 登録日 | 2011-08-24 | 公開日 | 2011-11-30 | 最終更新日 | 2011-12-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of potent and highly selective thienopyridine janus kinase 2 inhibitors. J.Med.Chem., 54, 2011
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3UZP
| crystal structure of ck1d with PF670462 from P21 crystal form | 分子名称: | 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine, Casein kinase I isoform delta | 著者 | Huang, X. | 登録日 | 2011-12-07 | 公開日 | 2012-01-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor. J.Med.Chem., 55, 2012
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3TJD
| co-crystal structure of Jak2 with thienopyridine 19 | 分子名称: | 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 | 著者 | Huang, X. | 登録日 | 2011-08-24 | 公開日 | 2011-11-30 | 最終更新日 | 2011-12-28 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Discovery of potent and highly selective thienopyridine janus kinase 2 inhibitors. J.Med.Chem., 54, 2011
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3UYT
| crystal structure of ck1d with PF670462 from P1 crystal form | 分子名称: | 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine, Casein kinase I isoform delta, SULFATE ION | 著者 | Huang, X. | 登録日 | 2011-12-06 | 公開日 | 2012-01-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor. J.Med.Chem., 55, 2012
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3UYS
| Crystal structure of apo human ck1d | 分子名称: | Casein kinase I isoform delta, SULFATE ION | 著者 | Huang, X. | 登録日 | 2011-12-06 | 公開日 | 2012-01-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor. J.Med.Chem., 55, 2012
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4HNM
| Crystal structure of human catenin-beta-like 1 56 kDa fragment | 分子名称: | Beta-catenin-like protein 1 | 著者 | Du, Z, Huang, X, Wang, G, Wu, Y. | 登録日 | 2012-10-19 | 公開日 | 2013-07-31 | 最終更新日 | 2013-08-21 | 実験手法 | X-RAY DIFFRACTION (2.9001 Å) | 主引用文献 | The structure of full-length human CTNNBL1 reveals a distinct member of the armadillo-repeat protein family. Acta Crystallogr.,Sect.D, 69, 2013
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4HNF
| Crystal structure of ck1d in complex with pf4800567 | 分子名称: | 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Casein kinase I isoform delta | 著者 | Huang, X, Long, A.M, Zhao, H. | 登録日 | 2012-10-19 | 公開日 | 2012-11-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. J.Med.Chem., 55, 2012
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4HOK
| crystal structure of apo ck1e | 分子名称: | Casein kinase I isoform epsilon, SULFATE ION | 著者 | Huang, X, Long, A.M, Zhao, H. | 登録日 | 2012-10-22 | 公開日 | 2012-11-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. J.Med.Chem., 55, 2012
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5VDH
| Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607, Glycine, and Ivermectin | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Shaffer, P.L, Huang, X, Chen, H. | 登録日 | 2017-04-03 | 公開日 | 2017-05-24 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Crystal Structures of Human GlyR alpha 3 Bound to Ivermectin. Structure, 25, 2017
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4H07
| Complex of G65T Myoglobin with Phenol in its Proximal Cavity | 分子名称: | 1,2-ETHANEDIOL, Myoglobin, PHENOL, ... | 著者 | Lebioda, L, Lovelace, L.L, Celeste, L.R, Huang, X, Wang, C, Shengfang, S, Dawson, J.H. | 登録日 | 2012-09-07 | 公開日 | 2012-11-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | 主引用文献 | Complex of myoglobin with phenol bound in a proximal cavity. Acta Crystallogr.,Sect.F, 68, 2012
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4HNI
| crystal structure of ck1e in complex with PF4800567 | 分子名称: | 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Casein kinase I isoform epsilon, SULFATE ION | 著者 | Huang, X, Long, A.M, Zhao, H. | 登録日 | 2012-10-19 | 公開日 | 2012-11-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. J.Med.Chem., 55, 2012
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4HBM
| Ordering of the N Terminus of Human MDM2 by Small Molecule Inhibitors | 分子名称: | E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-hydroxybutan-2-yl]-2-oxopiperidin-3-yl}acetic acid | 著者 | Huang, X. | 登録日 | 2012-09-28 | 公開日 | 2012-10-17 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Ordering of the N-terminus of human MDM2 by small molecule inhibitors. J.Am.Chem.Soc., 134, 2012
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4H0B
| Complex of G65T Myoglobin with DMSO in its Distal Cavity | 分子名称: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Myoglobin, ... | 著者 | Lebioda, L, Lovelace, L.L, Celeste, L.R, Huang, X, Wang, C, Shengfang, S, Dawson, J.H. | 登録日 | 2012-09-07 | 公開日 | 2012-11-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | Complex of myoglobin with phenol bound in a proximal cavity. Acta Crystallogr.,Sect.F, 68, 2012
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4HM9
| Crystal structure of full-length human catenin-beta-like 1 | 分子名称: | Beta-catenin-like protein 1 | 著者 | Du, Z, Huang, X, Wang, G, Wu, Y. | 登録日 | 2012-10-18 | 公開日 | 2013-07-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.1001 Å) | 主引用文献 | The structure of full-length human CTNNBL1 reveals a distinct member of the armadillo-repeat protein family. Acta Crystallogr.,Sect.D, 69, 2013
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