4DVI

Crystal structure of Tankyrase 1 with IWR2

Summary for 4DVI

• Entry DOI: 10.2210/pdb4dvi/pdb
• Related: 2RF5
• Descriptor: Tankyrase-1, ZINC ION, 4-[(3aR,4S,7R,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(4-methylquinolin-8-yl)benzamide, ... (4 entities in total)
• Functional Keywords: tankyrase, parp, inhibitor, iwr2, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: O95271
• Total number of polymer chains: 2
• Total formula weight: 51060.41

Authors

Huang, X. (deposition date: 2012-02-23, release date: 2012-04-04, Last modification date: 2024-02-28)

• Primary citation: Gunaydin, H.,Gu, Y.,Huang, X.; Novel binding mode of a potent and selective tankyrase inhibitor.; Plos One, 7:e33740-e33740, 2012; PubMed: 22438990; DOI: 10.1371/journal.pone.0033740

Experimental method

X-RAY DIFFRACTION (1.9 Å)