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2OFV

crystal structure of aminoquinazoline 1 bound to Lck

Summary for 2OFV
Entry DOI10.2210/pdb2ofv/pdb
DescriptorProto-oncogene tyrosine-protein kinase LCK, 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE (3 entities in total)
Functional Keywordslck, kinase domain, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P06239
Total number of polymer chains2
Total formula weight64962.12
Authors
Huang, X. (deposition date: 2007-01-04, release date: 2007-02-27, Last modification date: 2023-08-30)
Primary citationDiMauro, E.F.,Newcomb, J.,Nunes, J.J.,Bemis, J.E.,Boucher, C.,Buchanan, J.L.,Buckner, W.H.,Cee, V.J.,Chai, L.,Deak, H.L.,Epstein, L.F.,Faust, T.,Gallant, P.,Geuns-Meyer, S.D.,Gore, A.,Gu, Y.,Henkle, B.,Hodous, B.L.,Hsieh, F.,Huang, X.,Kim, J.L.,Lee, J.H.,Martin, M.W.,Masse, C.E.,McGowan, D.C.,Metz, D.,Mohn, D.,Morgenstern, K.A.,Oliveira-dos-Santos, A.,Patel, V.F.,Powers, D.,Rose, P.E.,Schneider, S.,Tomlinson, S.A.,Tudor, Y.-Y.,Turci, S.M.,Welcher, A.A.,White, R.D.,Zhao, H.,Zhu, L.,Zhu, X.
Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity
J.Med.Chem., 49:5671-, 2006
Cited by
PubMed: 16970394
DOI: 10.1021/jm0605482
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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