2OFV
crystal structure of aminoquinazoline 1 bound to Lck
Summary for 2OFV
Entry DOI | 10.2210/pdb2ofv/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase LCK, 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE (3 entities in total) |
Functional Keywords | lck, kinase domain, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P06239 |
Total number of polymer chains | 2 |
Total formula weight | 64962.12 |
Authors | Huang, X. (deposition date: 2007-01-04, release date: 2007-02-27, Last modification date: 2023-08-30) |
Primary citation | DiMauro, E.F.,Newcomb, J.,Nunes, J.J.,Bemis, J.E.,Boucher, C.,Buchanan, J.L.,Buckner, W.H.,Cee, V.J.,Chai, L.,Deak, H.L.,Epstein, L.F.,Faust, T.,Gallant, P.,Geuns-Meyer, S.D.,Gore, A.,Gu, Y.,Henkle, B.,Hodous, B.L.,Hsieh, F.,Huang, X.,Kim, J.L.,Lee, J.H.,Martin, M.W.,Masse, C.E.,McGowan, D.C.,Metz, D.,Mohn, D.,Morgenstern, K.A.,Oliveira-dos-Santos, A.,Patel, V.F.,Powers, D.,Rose, P.E.,Schneider, S.,Tomlinson, S.A.,Tudor, Y.-Y.,Turci, S.M.,Welcher, A.A.,White, R.D.,Zhao, H.,Zhu, L.,Zhu, X. Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity J.Med.Chem., 49:5671-, 2006 Cited by PubMed: 16970394DOI: 10.1021/jm0605482 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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