2OFV
crystal structure of aminoquinazoline 1 bound to Lck
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Proto-oncogene tyrosine-protein kinase LCK | polymer | 277 | 32058.7 | 2 | UniProt (P06239) Pfam (PF07714) In PDB | Homo sapiens (human) | p56-LCK, Lymphocyte cell-specific protein-tyrosine kinase, LSK, T cell- specific protein-tyrosine kinase |
| 2 | A, B | 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE | non-polymer | 422.4 | 2 | Chemie (242) | |||
| 3 | water | water | 18.0 | 271 | Chemie (HOH) |
Sequence modifications
A, B: 226 - 502 (UniProt: P06239)
| PDB | External Database | Details |
|---|---|---|
| Thr 226 | - | cloning artifact |
| Gln 227 | - | cloning artifact |
| Lys 228 | - | cloning artifact |
| Pro 229 | - | cloning artifact |
| Gln 230 | - | cloning artifact |
| Lys 231 | - | cloning artifact |
| Thr 499 | - | cloning artifact |
| Ala 500 | - | cloning artifact |
| Thr 501 | - | cloning artifact |
| Glu 502 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64117.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 844.8 | |
| All* | Total formula weight | 64962.1 |
