4RPV

co-crystal structure of Pim1 with compound 3

Summary for 4RPV

Entry DOI	10.2210/pdb4rpv/pdb
Descriptor	Serine/threonine-protein kinase pim-1, (3S)-1-{6-[5-(2,6-difluorophenyl)-2H-indazol-3-yl]pyrazin-2-yl}piperidin-3-amine (2 entities in total)
Functional Keywords	pim1, kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	46714.64
Authors	Huang, X. (deposition date: 2014-10-31, release date: 2015-02-04, Last modification date: 2024-02-28)
Primary citation	Wang, H.L.,Cee, V.J.,Chavez, F.,Lanman, B.A.,Reed, A.B.,Wu, B.,Guerrero, N.,Lipford, J.R.,Sastri, C.,Winston, J.,Andrews, K.L.,Huang, X.,Lee, M.R.,Mohr, C.,Xu, Y.,Zhou, Y.,Tasker, A.S. The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors. Bioorg.Med.Chem.Lett., 25:834-840, 2015 Cited by PubMed: 25597005 DOI: 10.1016/j.bmcl.2014.12.068 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.05 Å)

Structure validation