3UZP

crystal structure of ck1d with PF670462 from P21 crystal form

Summary for 3UZP

Entry DOI	10.2210/pdb3uzp/pdb
Related	1CKI 3UYS 3UYT
Descriptor	Casein kinase I isoform delta, 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine (3 entities in total)
Functional Keywords	ck1d, kinase, inhibitor, pf670462, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P48730
Total number of polymer chains	2
Total formula weight	69376.11
Authors	Huang, X. (deposition date: 2011-12-07, release date: 2012-01-11, Last modification date: 2024-02-28)
Primary citation	Long, A.,Zhao, H.,Huang, X. Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor. J.Med.Chem., 55:956-960, 2012 Cited by PubMed Abstract: Casein kinase 1 delta (CK1δ) and its closest homologue CK1ε are key regulators of diverse cellular growth and survival processes such as Wnt signaling, DNA repair, and circadian rhythms. We report three crystal structures of the kinase domain of human CK1δ, one apo and two complexed with a potent and selective CK1δ/ε inhibitor PF670462 in two different crystal forms. These structures provide a molecular basis for the strong and specific inhibitor interactions and suggest clues for further development of CK1δ/ε inhibitors. PubMed: 22168824 DOI: 10.1021/jm201387s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation