8X3S

Crystal structure of human WDR5 in complex with PTEN

Summary for 8X3S

• Entry DOI: 10.2210/pdb8x3s/pdb
• Descriptor: WD repeat-containing protein 5, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (3 entities in total)
• Functional Keywords: complex, cell proliferation, cancer, cell cycle
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 37944.85

Authors

Liu, Y.,Huang, X.,Shang, X. (deposition date: 2023-11-14, release date: 2024-05-29)

• Primary citation: Huang, X.,Zhang, C.,Shang, X.,Chen, Y.,Xiao, Q.,Wei, Z.,Wang, G.,Zhen, X.,Xu, G.,Min, J.,Shen, S.,Liu, Y.; The NTE domain of PTEN alpha / beta promotes cancer progression by interacting with WDR5 via its SSSRRSS motif.; Cell Death Dis, 15:335-335, 2024; PubMed: 38744853; DOI: 10.1038/s41419-024-06714-6

Experimental method

X-RAY DIFFRACTION (1.87 Å)