8X3S

Crystal structure of human WDR5 in complex with PTEN

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV

Chain	Residue	Details
A	LEU75-VAL89
A	ILE117-VAL131
A	ILE159-THR173
A	ILE247-LEU261

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00590

Chain	Residue	Details
B	PRO10
A	PHE106
A	PHE236
A	GLU295

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS85

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site_id	SWS_FT_FI3
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS0
A	LYS19

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 456

Chain	Residue	Details
B	PRO10	covalent catalysis
B	GLN16	transition state stabiliser

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