4HOK
crystal structure of apo ck1e
Summary for 4HOK
| Entry DOI | 10.2210/pdb4hok/pdb |
| Related | 4HNF 4HNI |
| Descriptor | Casein kinase I isoform epsilon, SULFATE ION (3 entities in total) |
| Functional Keywords | ck1e, kinase, inhibitor, pf 4800567, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 12 |
| Total formula weight | 412940.11 |
| Authors | Huang, X.,Long, A.M.,Zhao, H. (deposition date: 2012-10-22, release date: 2012-11-14, Last modification date: 2024-02-28) |
| Primary citation | Long, A.M.,Zhao, H.,Huang, X. Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. J.Med.Chem., 55:10307-10311, 2012 Cited by PubMed Abstract: Casein kinase 1 epsilon (CK1ε) and its closest homologue CK1δ are key regulators of diverse cellular processes. We report two crystal structures of PF4800567, a potent and selective inhibitor of CK1ε, bound to the kinase domains of human CK1ε and CK1δ as well as one apo CK1ε crystal structure. These structures provide a molecular basis for the strong and specific inhibitor interactions with CK1ε and suggest clues for further development of CK1δ inhibitors. PubMed: 23106386DOI: 10.1021/jm301336n PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.77 Å) |
Structure validation
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