7F1R
 
 | | Cryo-EM structure of the chemokine receptor CCR5 in complex with RANTES and Gi | | 分子名称: | C-C motif chemokine 5,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | | 登録日 | 2021-06-09 | | 公開日 | 2021-07-14 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.
Nat Commun, 12, 2021
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7F1T
 | | Crystal structure of the human chemokine receptor CCR5 in complex with MIP-1a | | 分子名称: | C-C motif chemokine 3,C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ZINC ION | | 著者 | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | | 登録日 | 2021-06-09 | | 公開日 | 2021-07-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.
Nat Commun, 12, 2021
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7F1S
 | | Cryo-EM structure of the apo chemokine receptor CCR5 in complex with Gi | | 分子名称: | C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | | 登録日 | 2021-06-09 | | 公開日 | 2021-07-14 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.
Nat Commun, 12, 2021
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7F1Q
 | | Cryo-EM structure of the chemokine receptor CCR5 in complex with MIP-1a and Gi | | 分子名称: | C-C motif chemokine 3,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | | 登録日 | 2021-06-09 | | 公開日 | 2021-07-14 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.
Nat Commun, 12, 2021
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4BKG
 | | crystal structure of human diSUMO-2 | | 分子名称: | SMALL UBIQUITIN-RELATED MODIFIER 2 | | 著者 | Keusekotten, K, Bade, V.N, Meyer-Teschendorf, K, Sriramachandran, A, Fischer-Schrader, K, Krause, A, Horst, C, Hofmann, K, Dohmen, R.J, Praefcke, G.J.K. | | 登録日 | 2013-04-25 | | 公開日 | 2013-11-06 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Multivalent Interactions of the Sumo-Interaction Motifs in the Ring-Finger Protein 4 (Rnf4) Determine the Specificity for Chains of the Small Ubiquitin-Related Modifier (Sumo).
Biochem.J., 457, 2014
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1N7D
 | | Extracellular domain of the LDL receptor | | 分子名称: | 12-TUNGSTOPHOSPHATE, CALCIUM ION, Low-density lipoprotein receptor, ... | | 著者 | Rudenko, G, Henry, L, Henderson, K, Ichtchenko, K, Brown, M.S, Goldstein, J.L, Deisenhofer, J. | | 登録日 | 2002-11-13 | | 公開日 | 2003-01-21 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Structure of the LDL receptor extracellular domain at endosomal pH
Science, 298, 2002
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5FR2
 | | Farnesylated RhoA-GDP in complex with RhoGDI-alpha, lysine acetylated at K178 | | 分子名称: | FARNESYL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Kuhlmann, N, Wroblowski, S, Knyphausen, P, de Boor, S, Brenig, J, Zienert, A.Y, Meyer-Teschendorf, K, Praefcke, G.J.K, Nolte, H, Krueger, M, Schacherl, M, Baumann, U, James, L.C, Chin, J.W, Lammers, M. | | 登録日 | 2015-12-15 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | | 主引用文献 | Structural and Mechanistic Insights Into the Regulation of the Fundamental Rho-Regulator Rhogdi Alpha by Lysine Acetylation.
J.Biol.Chem., 291, 2016
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2VCQ
 | | Complex structure of prostaglandin D2 synthase at 1.95A. | | 分子名称: | 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole, GLUTATHIONE, GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE | | 著者 | Hohwy, M, Spadola, L, Lundquist, B, von Wachenfeldt, K, Persdotter, S, Hawtin, P, Dahmen, J, Groth-Clausen, I, Folmer, R.H.A, Edman, K. | | 登録日 | 2007-09-26 | | 公開日 | 2008-04-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
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2VCX
 | | Complex structure of prostaglandin D2 synthase at 2.1A. | | 分子名称: | GLUTATHIONE, GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, MAGNESIUM ION, ... | | 著者 | Hohwy, M, Spadola, L, Lundquist, B, von Wachenfeldt, K, Persdotter, S, Hawtin, P, Dahmen, J, Groth-Clausen, I, Folmer, R.H.A, Edman, K. | | 登録日 | 2007-09-27 | | 公開日 | 2008-04-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
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2VCZ
 | | Complex structure of prostaglandin D2 synthase at 1.95A. | | 分子名称: | 3-(4-nitrophenyl)-1H-pyrazole, GLUTATHIONE, GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE | | 著者 | Hohwy, M, Spadola, L, Lundquist, B, von Wachenfeldt, K, Persdotter, S, Hawtin, P, Dahmen, J, Groth-Clausen, I, Folmer, R.H.A, Edman, K. | | 登録日 | 2007-09-28 | | 公開日 | 2008-04-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
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2VD0
 | | Complex structure of prostaglandin D2 synthase at 2.2A. | | 分子名称: | 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid, GLUTATHIONE, GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, ... | | 著者 | Hohwy, M, Spadola, L, Lundquist, B, von Wachenfeldt, K, Persdotter, S, Hawtin, P, Dahmen, J, Groth-Clausen, I, Folmer, R.H.A, Edman, K. | | 登録日 | 2007-09-28 | | 公開日 | 2008-04-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
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2VCW
 | | Complex structure of prostaglandin D2 synthase at 1.95A. | | 分子名称: | 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID, GLUTATHIONE, GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE | | 著者 | Hohwy, M, Spadola, L, Lundquist, B, von Wachenfeldt, K, Persdotter, S, Hawtin, P, Dahmen, J, Groth-Clausen, I, Folmer, R.H.A, Edman, K. | | 登録日 | 2007-09-27 | | 公開日 | 2008-04-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
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2VD1
 | | Complex structure of prostaglandin D2 synthase at 2.25A. | | 分子名称: | 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid, GLUTATHIONE, GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, ... | | 著者 | Hohwy, M, Spadola, L, Lundquist, B, von Wachenfeldt, K, Persdotter, S, Hawtin, P, Dahmen, J, Groth-Clausen, I, Folmer, R.H.A, Edman, K. | | 登録日 | 2007-09-28 | | 公開日 | 2008-04-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
J.Med.Chem., 51, 2008
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5ANM
 | | Crystal structure of IgE Fc in complex with a neutralizing antibody | | 分子名称: | IG EPSILON CHAIN C REGION, IMMUNOGLOBULIN G, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Cohen, E.S, Dobson, C.L, Kack, H, Wang, B, Sims, D.A, Lloyd, C.O, England, E, Rees, D.G, Guo, H, Karagiannis, S.N, O'Brien, S, Persdotter, S, Ekdahl, H, Butler, R, Keyes, F, Oakley, S, Carlsson, M, Briend, E, Wilkinson, T, Anderson, I.K, Monk, P.D, vonWachenfeldt, K, Eriksson, P.O, Gould, H.J, Vaughan, T.J, May, R.D. | | 登録日 | 2015-09-07 | | 公開日 | 2015-09-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | A Novel Ige-Neutralizing Antibody for the Treatment of Severe Uncontrolled Asthma.
Mabs, 6, 2015
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5GGM
 | | The NMR structure of calmodulin in CTAB reverse micelles | | 分子名称: | CALCIUM ION, Calmodulin, TERBIUM(III) ION | | 著者 | Xu, G, Cheng, K, Wu, Q, Liu, M, Li, C. | | 登録日 | 2016-06-16 | | 公開日 | 2016-09-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The NMR structure of calmodulin in CTAB reverse micelles
To Be Published
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2V3W
 | | Crystal structure of the benzoylformate decarboxylase variant L461A from Pseudomonas putida | | 分子名称: | BENZOYLFORMATE DECARBOXYLASE, MAGNESIUM ION, SULFATE ION, ... | | 著者 | Gocke, D, Walter, L, Gauchenova, K, Kolter, G, Knoll, M, Berthold, C.L, Schneider, G, Pleiss, J, Mueller, M, Pohl, M. | | 登録日 | 2007-06-25 | | 公開日 | 2008-01-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Rational Protein Design of Thdp-Dependent Enzymes-Engineering Stereoselectivity.
Chembiochem, 9, 2008
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2JYW
 | | Solution structure of C-terminal domain of APOBEC3G | | 分子名称: | DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | | 著者 | Chen, K, Harjes, E, Gross, P.J, Fahmy, A, Lu, Y, Shindo, K, Harris, R.S, Matsuo, H. | | 登録日 | 2007-12-20 | | 公開日 | 2008-02-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G.
Nature, 452, 2008
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1GAO
 | | CRYSTAL STRUCTURE OF THE L44S MUTANT OF FERREDOXIN I | | 分子名称: | FE3-S4 CLUSTER, FERREDOXIN I, IRON/SULFUR CLUSTER | | 著者 | Stout, C.D, Burgess, B.K, Prasad, G.S, Sridhar, V, Jung, Y.S. | | 登録日 | 2000-11-30 | | 公開日 | 2000-12-13 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Azotobacter vinelandii ferredoxin I: a sequence and structure comparison approach to alteration of [4Fe-4S]2+/+ reduction potential.
J.Biol.Chem., 277, 2002
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1G3O
 | | CRYSTAL STRUCTURE OF V19E MUTANT OF FERREDOXIN I | | 分子名称: | 7FE FERREDOXIN I, FE3-S4 CLUSTER, IRON/SULFUR CLUSTER | | 著者 | Stout, C.D, Burgess, B.K, Bonagura, C.A, Jung, Y.S. | | 登録日 | 2000-10-24 | | 公開日 | 2000-11-06 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Azotobacter vinelandii ferredoxin I: a sequence and structure comparison approach to alteration of [4Fe-4S]2+/+ reduction potential
J.Biol.Chem., 277, 2002
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1G6B
 | | CRYSTAL STRUCTURE OF P47S MUTANT OF FERREDOXIN I | | 分子名称: | 7FE FERREDOXIN I, FE3-S4 CLUSTER, IRON/SULFUR CLUSTER | | 著者 | Stout, C.D, Burgess, B.K, Bonagura, C.A, Jung, Y.S. | | 登録日 | 2000-11-03 | | 公開日 | 2000-11-22 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Azotobacter vinelandii ferredoxin I: a sequence and structure comparison approach to alteration of [4Fe-4S]2+/+ reduction potential.
J.Biol.Chem., 277, 2002
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7TAI
 | | Structure of STEAP2 in complex with ligands | | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Wang, L, Chen, K.H, Zhou, M. | | 登録日 | 2021-12-20 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-02-07 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Mechanism of stepwise electron transfer in six-transmembrane epithelial antigen of the prostate (STEAP) 1 and 2.
Elife, 12, 2023
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1Q4K
 | | The polo-box domain of Plk1 in complex with a phospho-peptide | | 分子名称: | Phospho-peptide sequence Met.Gln.Ser.pThr.Pro.Leu, Serine/threonine-protein kinase PLK | | 著者 | Cheng, K, Lowe, E.D, Sinclair, J, Nigg, E.A, Johnson, L.N. | | 登録日 | 2003-08-04 | | 公開日 | 2003-11-11 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex.
Embo J., 22, 2003
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5V2N
 | | Crystal Structure of APO Human SETD8 | | 分子名称: | 1,2-ETHANEDIOL, N-lysine methyltransferase KMT5A | | 著者 | Skene, R.J. | | 登録日 | 2017-03-05 | | 公開日 | 2018-03-07 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The dynamic conformational landscape of the protein methyltransferase SETD8.
Elife, 8, 2019
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7T6B
 | | Structure of S1PR2-heterotrimeric G13 signaling complex | | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Li, X, Chen, H. | | 登録日 | 2021-12-13 | | 公開日 | 2022-04-06 | | 最終更新日 | 2022-06-29 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Structure of S1PR2-heterotrimeric G 13 signaling complex.
Sci Adv, 8, 2022
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5UX4
 | | Crystal Structure of Rat Cathepsin D with (5S)-3-(5,6-dihydro-2H-pyran-3-yl)-1-fluoro- 7-(2-fluoropyridin-3-yl)spiro[chromeno[2,3- c]pyridine-5,4'-[1,3]oxazol]-2'-amine | | 分子名称: | (5S)-3-(5,6-dihydro-2H-pyran-3-yl)-1-fluoro-7-(2-fluoropyridin-3-yl)spiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Sickmier, A. | | 登録日 | 2017-02-22 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.805 Å) | | 主引用文献 | Development of 2-aminooxazoline 3-azaxanthene beta-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D.
Medchemcomm, 8, 2017
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