2VD0

Complex structure of prostaglandin D2 synthase at 2.2A.

Summary for 2VD0

Entry DOI	10.2210/pdb2vd0/pdb
Related	1IYH 1IYI 1V40 2VCQ 2VCW 2VCX 2VCZ
Descriptor	GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid, ... (5 entities in total)
Functional Keywords	prostaglandin biosynthesis, fatty acid biosynthesis, prostaglandin d2 synthase, pgds, asthma, cytoplasm, isomerase, lipid synthesis
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: O60760
Total number of polymer chains	4
Total formula weight	94824.71
Authors	Hohwy, M.,Spadola, L.,Lundquist, B.,von Wachenfeldt, K.,Persdotter, S.,Hawtin, P.,Dahmen, J.,Groth-Clausen, I.,Folmer, R.H.A.,Edman, K. (deposition date: 2007-09-28, release date: 2008-04-15, Last modification date: 2023-12-13)
Primary citation	Hohwy, M.,Spadola, L.,Lundquist, B.,Hawtin, P.,Dahmen, J.,Groth-Clausen, I.,Nilsson, E.,Persdotter, S.,Von Wachenfeldt, K.,Folmer, R.H.A.,Edman, K. Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design. J.Med.Chem., 51:2178-, 2008 Cited by PubMed: 18341273 DOI: 10.1021/JM701509K PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation