2VCQ

Complex structure of prostaglandin D2 synthase at 1.95A.

Summary for 2VCQ

Entry DOI	10.2210/pdb2vcq/pdb
Related	1IYH 1IYI 1V40
Descriptor	GLUTATHIONE-REQUIRING PROSTAGLANDIN D SYNTHASE, GLUTATHIONE, 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole, ... (4 entities in total)
Functional Keywords	prostaglandin biosynthesis, fatty acid biosynthesis, prostaglandin d2 synthase, pgds, asthma, cytoplasm, isomerase, lipid synthesis
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: O60760
Total number of polymer chains	4
Total formula weight	95346.27
Authors	Hohwy, M.,Spadola, L.,Lundquist, B.,von Wachenfeldt, K.,Persdotter, S.,Hawtin, P.,Dahmen, J.,Groth-Clausen, I.,Folmer, R.H.A.,Edman, K. (deposition date: 2007-09-26, release date: 2008-04-15, Last modification date: 2023-12-13)
Primary citation	Hohwy, M.,Spadola, L.,Lundquist, B.,Hawtin, P.,Dahmen, J.,Groth-Clausen, I.,Nilsson, E.,Persdotter, S.,Von Wachenfeldt, K.,Folmer, R.H.A.,Edman, K. Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design. J.Med.Chem., 51:2178-, 2008 Cited by PubMed: 18341273 DOI: 10.1021/JM701509K PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation