5UX4

Crystal Structure of Rat Cathepsin D with (5S)-3-(5,6-dihydro-2H-pyran-3-yl)-1-fluoro- 7-(2-fluoropyridin-3-yl)spiro[chromeno[2,3- c]pyridine-5,4'-[1,3]oxazol]-2'-amine

Summary for 5UX4

• Entry DOI: 10.2210/pdb5ux4/pdb
• Descriptor: Cathepsin D, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: cathepsin d, beta amyloid cleaving enzyme, bace1, hydrolase
• Biological source: Rattus norvegicus (Rat)
• Total number of polymer chains: 2
• Total formula weight: 95635.91

Authors

Sickmier, A. (deposition date: 2017-02-22, release date: 2018-06-13, Last modification date: 2023-10-04)

• Primary citation: Low, J.D.,Bartberger, M.D.,Chen, K.,Cheng, Y.,Fielden, M.R.,Gore, V.,Hickman, D.,Liu, Q.,Allen Sickmier, E.,Vargas, H.M.,Werner, J.,White, R.D.,Whittington, D.A.,Wood, S.,Minatti, A.E.; Development of 2-aminooxazoline 3-azaxanthene beta-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D.; Medchemcomm, 8:1196-1206, 2017; PubMed: 30108829; DOI: 10.1039/c7md00106a

Experimental method

X-RAY DIFFRACTION (2.805 Å)