5UX4

Crystal Structure of Rat Cathepsin D with (5S)-3-(5,6-dihydro-2H-pyran-3-yl)-1-fluoro- 7-(2-fluoropyridin-3-yl)spiro[chromeno[2,3- c]pyridine-5,4'-[1,3]oxazol]-2'-amine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0004175	molecular_function	endopeptidase activity
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005768	cellular_component	endosome
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0010008	cellular_component	endosome membrane
A	0016787	molecular_function	hydrolase activity
A	0030163	biological_process	protein catabolic process
A	0031667	biological_process	response to nutrient levels
A	0031904	cellular_component	endosome lumen
A	0038020	biological_process	insulin receptor recycling
A	0042159	biological_process	lipoprotein catabolic process
A	0042277	molecular_function	peptide binding
A	0042470	cellular_component	melanosome
A	0043065	biological_process	positive regulation of apoptotic process
A	0045121	cellular_component	membrane raft
A	0060441	biological_process	epithelial tube branching involved in lung morphogenesis
A	0070001	molecular_function	aspartic-type peptidase activity
A	0070201	biological_process	regulation of establishment of protein localization
A	0097194	biological_process	execution phase of apoptosis
A	0098830	cellular_component	presynaptic endosome
A	0098982	cellular_component	GABA-ergic synapse
A	0099532	biological_process	synaptic vesicle endosomal processing
A	1901143	biological_process	insulin catabolic process
B	0000045	biological_process	autophagosome assembly
B	0004175	molecular_function	endopeptidase activity
B	0004190	molecular_function	aspartic-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0005768	cellular_component	endosome
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0010008	cellular_component	endosome membrane
B	0016787	molecular_function	hydrolase activity
B	0030163	biological_process	protein catabolic process
B	0031667	biological_process	response to nutrient levels
B	0031904	cellular_component	endosome lumen
B	0038020	biological_process	insulin receptor recycling
B	0042159	biological_process	lipoprotein catabolic process
B	0042277	molecular_function	peptide binding
B	0042470	cellular_component	melanosome
B	0043065	biological_process	positive regulation of apoptotic process
B	0045121	cellular_component	membrane raft
B	0060441	biological_process	epithelial tube branching involved in lung morphogenesis
B	0070001	molecular_function	aspartic-type peptidase activity
B	0070201	biological_process	regulation of establishment of protein localization
B	0097194	biological_process	execution phase of apoptosis
B	0098830	cellular_component	presynaptic endosome
B	0098982	cellular_component	GABA-ergic synapse
B	0099532	biological_process	synaptic vesicle endosomal processing
B	1901143	biological_process	insulin catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNLWV

Chain	Residue	Details
A	VAL30-VAL41
A	ALA223-GLY234

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24090084","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---