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5UX4

Crystal Structure of Rat Cathepsin D with (5S)-3-(5,6-dihydro-2H-pyran-3-yl)-1-fluoro- 7-(2-fluoropyridin-3-yl)spiro[chromeno[2,3- c]pyridine-5,4'-[1,3]oxazol]-2'-amine

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0004175molecular_functionendopeptidase activity
A0004190molecular_functionaspartic-type endopeptidase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0010008cellular_componentendosome membrane
A0016787molecular_functionhydrolase activity
A0030163biological_processprotein catabolic process
A0031667biological_processresponse to nutrient levels
A0031904cellular_componentendosome lumen
A0038020biological_processinsulin receptor recycling
A0042159biological_processlipoprotein catabolic process
A0042277molecular_functionpeptide binding
A0042470cellular_componentmelanosome
A0043065biological_processpositive regulation of apoptotic process
A0045121cellular_componentmembrane raft
A0060441biological_processepithelial tube branching involved in lung morphogenesis
A0070001molecular_functionaspartic-type peptidase activity
A0070201biological_processregulation of establishment of protein localization
A0098830cellular_componentpresynaptic endosome
A0098982cellular_componentGABA-ergic synapse
A0099003biological_processvesicle-mediated transport in synapse
A0099532biological_processsynaptic vesicle endosomal processing
A1901143biological_processinsulin catabolic process
B0000045biological_processautophagosome assembly
B0004175molecular_functionendopeptidase activity
B0004190molecular_functionaspartic-type endopeptidase activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0006508biological_processproteolysis
B0008233molecular_functionpeptidase activity
B0010008cellular_componentendosome membrane
B0016787molecular_functionhydrolase activity
B0030163biological_processprotein catabolic process
B0031667biological_processresponse to nutrient levels
B0031904cellular_componentendosome lumen
B0038020biological_processinsulin receptor recycling
B0042159biological_processlipoprotein catabolic process
B0042277molecular_functionpeptide binding
B0042470cellular_componentmelanosome
B0043065biological_processpositive regulation of apoptotic process
B0045121cellular_componentmembrane raft
B0060441biological_processepithelial tube branching involved in lung morphogenesis
B0070001molecular_functionaspartic-type peptidase activity
B0070201biological_processregulation of establishment of protein localization
B0098830cellular_componentpresynaptic endosome
B0098982cellular_componentGABA-ergic synapse
B0099003biological_processvesicle-mediated transport in synapse
B0099532biological_processsynaptic vesicle endosomal processing
B1901143biological_processinsulin catabolic process
Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNLWV
ChainResidueDetails
AVAL30-VAL41
AALA223-GLY234

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094
ChainResidueDetails
AASP33
AASP226
BASP33
BASP226

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN70
BASN70

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0007744|PubMed:24090084
ChainResidueDetails
AASN194
BASN194

227344

PDB entries from 2024-11-13

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