5ANM

Crystal structure of IgE Fc in complex with a neutralizing antibody

Summary for 5ANM

Entry DOI	10.2210/pdb5anm/pdb
Related	5ANS 5ANT
Descriptor	IMMUNOGLOBULIN G, IG EPSILON CHAIN C REGION, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	immune system, therapeutic antibody, igg, ige, asthma
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	9
Total formula weight	228131.06
Authors	Cohen, E.S.,Dobson, C.L.,Kack, H.,Wang, B.,Sims, D.A.,Lloyd, C.O.,England, E.,Rees, D.G.,Guo, H.,Karagiannis, S.N.,O'Brien, S.,Persdotter, S.,Ekdahl, H.,Butler, R.,Keyes, F.,Oakley, S.,Carlsson, M.,Briend, E.,Wilkinson, T.,Anderson, I.K.,Monk, P.D.,vonWachenfeldt, K.,Eriksson, P.O.,Gould, H.J.,Vaughan, T.J.,May, R.D. (deposition date: 2015-09-07, release date: 2015-09-30, Last modification date: 2024-01-10)
Primary citation	Cohen, E.S.,Dobson, C.L.,Kack, H.,Wang, B.,Sims, D.A.,Lloyd, C.O.,England, E.,Rees, D.G.,Guo, H.,Karagiannis, S.N.,O'Brien, S.,Persdotter, S.,Ekdahl, H.,Butler, R.,Keyes, F.,Oakley, S.,Carlsson, M.,Briend, E.,Wilkinson, T.,Anderson, I.K.,Monk, P.D.,Von Wachenfeldt, K.,Eriksson, P.F.,Gould, H.J.,Vaughan, T.J.,May, R.D. A Novel Ige-Neutralizing Antibody for the Treatment of Severe Uncontrolled Asthma. Mabs, 6:756-, 2015 Cited by PubMed: 24583620 DOI: 10.4161/MABS.28394 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation