5ANM
Crystal structure of IgE Fc in complex with a neutralizing antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, I (A, C, L) | IMMUNOGLOBULIN G | polymer | 217 | 22930.3 | 3 | HOMO SAPIENS (HUMAN) | ||
| 2 | B, D, H (B, D, H) | IMMUNOGLOBULIN G | polymer | 229 | 24752.9 | 3 | HOMO SAPIENS (HUMAN) | ||
| 3 | E, F, G (E, F, G) | IG EPSILON CHAIN C REGION | polymer | 242 | 27341.6 | 3 | UniProt (P01854) Pfam (PF07654) | HOMO SAPIENS (HUMAN) | IMMUNOGLOBULIN E |
| 4 | J (I) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
| 5 | K (J) | beta-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G42769XG) | |||
| 6 | L (K) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G00601VC) | |||
| 7 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
E, F, G: 330 - 547 (UniProt: P01854)
| PDB | External Database | Details |
|---|---|---|
| Ala 326 | - | expression tag |
| Asp 327 | - | expression tag |
| Pro 328 | - | expression tag |
| Cys 329 | - | expression tag |
| Asp 548 | - | expression tag |
| Tyr 549 | - | expression tag |
| Lys 550 | - | expression tag |
| Asp 551 | - | expression tag |
| Asp 552 | - | expression tag |
| Asp 553 | - | expression tag |
| Asp 554 | - | expression tag |
| Lys 555 | - | expression tag |
| Ala 556 | - | expression tag |
| Ala 557 | - | expression tag |
| His 558 | - | expression tag |
| His 559 | - | expression tag |
| His 560 | - | expression tag |
| His 561 | - | expression tag |
| His 562 | - | expression tag |
| His 563 | - | expression tag |
| His 564 | - | expression tag |
| His 565 | - | expression tag |
| His 566 | - | expression tag |
| His 567 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 225074.3 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 3056.8 | |
| All* | Total formula weight | 228131.1 |
