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1YVJ
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BU of 1yvj by Molmil
Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue
分子名称: (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE, Tyrosine-protein kinase JAK3
著者Boggon, T.J, Li, Y, Manley, P.W, Eck, M.J.
登録日2005-02-15
公開日2005-05-24
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog
Blood, 106, 2005
2AL6
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BU of 2al6 by Molmil
FERM domain of Focal Adhesion Kinase
分子名称: Focal adhesion kinase 1
著者Ceccarelli, D.F, Song, H.K, Poy, F, Schaller, M.D, Eck, M.J.
登録日2005-08-04
公開日2005-10-18
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal Structure of the FERM Domain of Focal Adhesion Kinase
J.Biol.Chem., 281, 2006
4R3R
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BU of 4r3r by Molmil
Crystal structures of EGFR in complex with Mig6
分子名称: Epidermal growth factor receptor, peptide from ERBB receptor feedback inhibitor 1'
著者Park, E, Kim, N, Yi, Z, Cho, A, Kim, K, Ficarro, S.B, Park, A, Park, W.Y, Murray, B, Meyerson, M, Beroukim, R, Marto, J.A, Cho, J, Eck, M.J.
登録日2014-08-17
公開日2015-08-12
最終更新日2015-09-16
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Nat.Struct.Mol.Biol., 22, 2015
1U5E
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BU of 1u5e by Molmil
Crystal Structure of a N-terminal Fragment of SKAP-Hom Containing Both the Helical Dimerization Domain and the PH Domain
分子名称: Src-associated adaptor protein
著者Tang, Y, Swanson, K.D, Neel, B.G, Eck, M.J.
登録日2004-07-27
公開日2005-07-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Basis for the Dimerization and Phosphoinositide Specificity of the Src Kinase-associated Phosphoproteins SKAP55 and SKAP-Hom
To be Published
2OTX
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BU of 2otx by Molmil
Crystal Structure of A N-terminal Fragment of SKAP-HOM Containing both the Helical Dimerization Domain and the PH Domain
分子名称: Src kinase-associated phosphoprotein 2
著者Tang, Y, Swanson, K.D, Neel, B.G, Eck, M.J.
登録日2007-02-09
公開日2007-03-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch.
Mol.Cell, 32, 2008
1U5D
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BU of 1u5d by Molmil
Crystal Structure of the PH domain of SKAP55
分子名称: SULFATE ION, Src Kinase-associated Phosphoprotein of 55 kDa
著者Tang, Y, Swanson, K.D, Neel, B.G, Eck, M.J.
登録日2004-07-27
公開日2005-07-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Basis for the Dimerization and Phosphoinositide Specificity of the Src Kinase-associated Phosphoproteins SKAP55 and SKAP-Hom
To be Published
1UX5
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BU of 1ux5 by Molmil
Crystal Structures of a Formin Homology-2 domain reveal a flexibly tethered dimer architecture
分子名称: BNI1 PROTEIN
著者Xu, Y, Moseley, J.B, Sagot, I, Poy, F, Pellman, D, Goode, B.L, Eck, M.J.
登録日2004-02-19
公開日2004-03-11
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structures of a Formin Homology-2 Domain Reveal a Tethered Dimer Architecture
Cell(Cambridge,Mass.), 116, 2004
2F31
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BU of 2f31 by Molmil
Crystal structure of the autoinhibitory switch in Formin mDia1; the DID/DAD complex
分子名称: Diaphanous protein homolog 1
著者Nezami, A.G, Poy, F, Eck, M.J.
登録日2005-11-18
公開日2006-05-30
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of the Autoinhibitory Switch in Formin mDia1
Structure, 14, 2006
2SHP
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BU of 2shp by Molmil
TYROSINE PHOSPHATASE SHP-2
分子名称: DODECANE-TRIMETHYLAMINE, SHP-2
著者Hof, P, Pluskey, S, Dhe-Paganon, S, Eck, M.J, Shoelson, S.E.
登録日1997-12-01
公開日1999-02-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the tyrosine phosphatase SHP-2.
Cell(Cambridge,Mass.), 92, 1998
2SRC
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BU of 2src by Molmil
CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP
分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TYROSINE-PROTEIN KINASE SRC
著者Xu, W, Doshi, A, Lei, M, Eck, M.J, Harrison, S.C.
登録日1998-12-29
公開日1999-07-22
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structures of c-Src reveal features of its autoinhibitory mechanism.
Mol.Cell, 3, 1999
1U5F
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BU of 1u5f by Molmil
Crystal Structure of the PH Domain of SKAP-Hom with 8 Vector-derived N-terminal Residues
分子名称: SULFATE ION, Src-associated adaptor protein
著者Tang, Y, Swanson, K.D, Neel, B.G, Eck, M.J.
登録日2004-07-27
公開日2005-07-26
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for the Dimerization and Phosphoinositide Specificity of the Src Kinase-associated Phosphoproteins SKAP55 and SKAP-Hom
To be Published
1UX4
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BU of 1ux4 by Molmil
Crystal structures of a Formin Homology-2 domain reveal a tethered-dimer architecture
分子名称: BNI1 PROTEIN
著者Xu, Y, Moseley, J.B, Sagot, I, Poy, F, Pellman, D, Goode, B.L, Eck, M.J.
登録日2004-02-19
公開日2004-03-11
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Crystal Structures of a Formin Homology-2 Domain Reveal a Tethered Dimer Architecture
Cell(Cambridge,Mass.), 116, 2004
2CBL
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BU of 2cbl by Molmil
N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE ON ZAP-70
分子名称: CALCIUM ION, PROTO-ONCOGENE CBL, ZAP-70
著者Meng, W, Sawasdikosol, S, Burakoff, S.J, Eck, M.J.
登録日1998-08-28
公開日1999-05-18
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
1U5G
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BU of 1u5g by Molmil
Crystal Structure of the PH Domain of SKAP-Hom
分子名称: Src-associated adaptor protein
著者Tang, Y, Swanson, K, Neel, B.G, Eck, M.J.
登録日2004-07-27
公開日2005-07-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch.
Mol.Cell, 32, 2008
6D2I
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BU of 6d2i by Molmil
JAK2 Pseudokinase V617F in complex with AT9283
分子名称: 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea, Tyrosine-protein kinase
著者Li, Q, Li, K, Eck, M.J.
登録日2018-04-13
公開日2019-03-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.192 Å)
主引用文献Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.
ACS Chem. Biol., 14, 2019
6NYB
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BU of 6nyb by Molmil
Structure of a MAPK pathway complex
分子名称: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, ADENOSINE-5'-DIPHOSPHATE, ...
著者Park, E, Rawson, S, Li, K, Jeon, H, Eck, M.J.
登録日2019-02-11
公開日2019-10-09
最終更新日2020-04-22
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
6D8E
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BU of 6d8e by Molmil
Discovery of a Highly Potent and Broadly Effective EGFR and HER2 Exon 20 Insertion Mutant Inhibitor
分子名称: (4-fluorophenyl)methyl {2-[(1-methyl-1H-pyrazol-3-yl)amino]pyrimidin-4-yl}[3-(propanoylamino)phenyl]carbamate, Epidermal growth factor receptor
著者Park, E, Eck, M.J.
登録日2018-04-26
公開日2018-07-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.537 Å)
主引用文献Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor.
Angew. Chem. Int. Ed. Engl., 57, 2018
6DUK
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BU of 6duk by Molmil
EGFR with an allosteric inhibitor
分子名称: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
著者Park, E, Eck, M.J.
登録日2018-06-21
公開日2019-06-05
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor.
Cancer Discov, 9, 2019
6P1L
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BU of 6p1l by Molmil
Crystal structure of EGFR in complex with EAI045
分子名称: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ...
著者Heppner, D.E, Eck, M.J.
登録日2019-05-20
公開日2019-12-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors.
Acs Med.Chem.Lett., 10, 2019
4LL0
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BU of 4ll0 by Molmil
EGFR L858R/T790M in complex with PD168393
分子名称: Epidermal growth factor receptor, N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide
著者Yun, C.H, Eck, M.J.
登録日2013-07-09
公開日2013-09-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Mechanism for activation of mutated epidermal growth factor receptors in lung cancer.
Proc.Natl.Acad.Sci.USA, 110, 2013
8DSW
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BU of 8dsw by Molmil
Crystal structure of EGFR kinase domain, Exon20 Insertion FQEA mutant
分子名称: Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Park, E, Eck, M.J.
登録日2022-07-23
公開日2023-09-27
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Structural basis for oncogenic activation of the epidermal growth factor receptor by the InsFQEA exon 20 insertion
To Be Published
4L01
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BU of 4l01 by Molmil
Crystal structure of the V658F apo Jak1 pseudokinase domain
分子名称: Tyrosine-protein kinase JAK1
著者Toms, A.V, Rogers, J.M, Eck, M.J.
登録日2013-05-30
公開日2013-09-04
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases.
Nat.Struct.Mol.Biol., 20, 2013
4L00
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BU of 4l00 by Molmil
Crystal structure of the apo Jak1 pseudokinase domain
分子名称: Tyrosine-protein kinase JAK1
著者Toms, A.V, Eck, M.J.
登録日2013-05-30
公開日2013-09-04
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases.
Nat.Struct.Mol.Biol., 20, 2013
8F7O
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BU of 8f7o by Molmil
BRAF kinase in complex with TAK580 (tovorafenib)
分子名称: 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide, Serine/threonine-protein kinase B-raf
著者Tkacik, E, Li, K, Gonzalez Del-Pino, G, Eck, M.J.
登録日2022-11-20
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (3.54 Å)
主引用文献Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib.
J.Biol.Chem., 299, 2023
8F7P
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BU of 8f7p by Molmil
BRAF kinase in complex with LXH254 (naporafenib)
分子名称: N-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide, Serine/threonine-protein kinase B-raf
著者Tkacik, E, Li, K, Gonzalez Del-Pino, G, Eck, M.J.
登録日2022-11-20
公開日2023-04-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib.
J.Biol.Chem., 299, 2023

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