4L01
Crystal structure of the V658F apo Jak1 pseudokinase domain
Summary for 4L01
Entry DOI | 10.2210/pdb4l01/pdb |
Related | 4L00 |
Descriptor | Tyrosine-protein kinase JAK1 (2 entities in total) |
Functional Keywords | kinase domain fold, regulatory, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Endomembrane system; Peripheral membrane protein: P23458 |
Total number of polymer chains | 2 |
Total formula weight | 69932.32 |
Authors | Toms, A.V.,Rogers, J.M.,Eck, M.J. (deposition date: 2013-05-30, release date: 2013-09-04, Last modification date: 2024-02-28) |
Primary citation | Toms, A.V.,Deshpande, A.,McNally, R.,Jeong, Y.,Rogers, J.M.,Kim, C.U.,Gruner, S.M.,Ficarro, S.B.,Marto, J.A.,Sattler, M.,Griffin, J.D.,Eck, M.J. Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases. Nat.Struct.Mol.Biol., 20:1221-1223, 2013 Cited by PubMed: 24013208DOI: 10.1038/nsmb.2673 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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