4L01

Crystal structure of the V658F apo Jak1 pseudokinase domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tyrosine-protein kinase JAK1	polymer	304	34966.2	2	UniProt (P23458) Pfam (PF07714) In PDB	Homo sapiens (human)	Janus kinase 1, JAK-1
2		water	water		18.0	221	Chemie (HOH)

Sequence modifications

A, B: 561 - 860 (UniProt: P23458)

PDB	External Database	Details
Gly 557	-	expression tag
Ser 558	-	expression tag
Thr 559	-	expression tag
Ser 560	-	expression tag
Phe 658	Val 658	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69932.3
All*	Total formula weight	69932.3

*Water molecules are not included.