4R3R
Crystal structures of EGFR in complex with Mig6
Summary for 4R3R
Entry DOI | 10.2210/pdb4r3r/pdb |
Related | 4R3P |
Descriptor | Epidermal growth factor receptor, peptide from ERBB receptor feedback inhibitor 1' (3 entities in total) |
Functional Keywords | kinase, phophorylation, atp hydrolysis, mig6, phosphorylation, transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 Cytoplasm : Q9UJM3 |
Total number of polymer chains | 2 |
Total formula weight | 38004.74 |
Authors | Park, E.,Kim, N.,Yi, Z.,Cho, A.,Kim, K.,Ficarro, S.B.,Park, A.,Park, W.Y.,Murray, B.,Meyerson, M.,Beroukim, R.,Marto, J.A.,Cho, J.,Eck, M.J. (deposition date: 2014-08-17, release date: 2015-08-12, Last modification date: 2015-09-16) |
Primary citation | Park, E.,Kim, N.,Ficarro, S.B.,Zhang, Y.,Lee, B.I.,Cho, A.,Kim, K.,Park, A.K.,Park, W.Y.,Murray, B.,Meyerson, M.,Beroukhim, R.,Marto, J.A.,Cho, J.,Eck, M.J. Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6. Nat.Struct.Mol.Biol., 22:703-711, 2015 Cited by PubMed: 26280531DOI: 10.1038/nsmb.3074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.25 Å) |
Structure validation
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