6DUK

EGFR with an allosteric inhibitor

Summary for 6DUK

• Entry DOI: 10.2210/pdb6duk/pdb
• Descriptor: Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
• Functional Keywords: allosteric inhibitor, egfr, oncoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 232792.27

Authors

Park, E.,Eck, M.J. (deposition date: 2018-06-21, release date: 2019-06-05, Last modification date: 2023-10-11)

• Primary citation: To, C.,Jang, J.,Chen, T.,Park, E.,Mushajiang, M.,De Clercq, D.J.H.,Xu, M.,Wang, S.,Cameron, M.D.,Heppner, D.E.,Shin, B.H.,Gero, T.W.,Yang, A.,Dahlberg, S.E.,Wong, K.K.,Eck, M.J.,Gray, N.S.,Janne, P.A.; Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor.; Cancer Discov, 9:926-943, 2019; PubMed: 31092401; DOI: 10.1158/2159-8290.CD-18-0903

Experimental method

X-RAY DIFFRACTION (2.2 Å)