Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004713 | molecular_function | protein tyrosine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006468 | biological_process | protein phosphorylation |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004713 | molecular_function | protein tyrosine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006468 | biological_process | protein phosphorylation |
C | 0004672 | molecular_function | protein kinase activity |
C | 0004713 | molecular_function | protein tyrosine kinase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0006468 | biological_process | protein phosphorylation |
D | 0004672 | molecular_function | protein kinase activity |
D | 0004713 | molecular_function | protein tyrosine kinase activity |
D | 0005524 | molecular_function | ATP binding |
D | 0006468 | biological_process | protein phosphorylation |
E | 0004672 | molecular_function | protein kinase activity |
E | 0004713 | molecular_function | protein tyrosine kinase activity |
E | 0005524 | molecular_function | ATP binding |
E | 0006468 | biological_process | protein phosphorylation |
F | 0004672 | molecular_function | protein kinase activity |
F | 0004713 | molecular_function | protein tyrosine kinase activity |
F | 0005524 | molecular_function | ATP binding |
F | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue MG A 1101 |
Chain | Residue |
A | ASN842 |
A | ASP855 |
A | ANP1102 |
A | HOH1217 |
site_id | AC2 |
Number of Residues | 28 |
Details | binding site for residue ANP A 1102 |
Chain | Residue |
A | VAL726 |
A | ALA743 |
A | LYS745 |
A | MET790 |
A | GLN791 |
A | LEU792 |
A | MET793 |
A | CYS797 |
A | ASP800 |
A | ASP837 |
A | ARG841 |
A | ASN842 |
A | LEU844 |
A | ASP855 |
A | MG1101 |
A | HOH1212 |
A | HOH1217 |
A | HOH1244 |
A | HOH1246 |
A | HOH1264 |
A | HOH1268 |
A | HOH1280 |
A | HOH1329 |
A | GLY719 |
A | SER720 |
A | GLY721 |
A | ALA722 |
A | GLY724 |
site_id | AC3 |
Number of Residues | 19 |
Details | binding site for residue JBJ A 1103 |
Chain | Residue |
A | PHE723 |
A | ALA743 |
A | ILE744 |
A | LYS745 |
A | LEU747 |
A | GLU749 |
A | ILE759 |
A | MET766 |
A | CYS775 |
A | ARG776 |
A | LEU777 |
A | LEU788 |
A | MET790 |
A | ASP855 |
A | PHE856 |
A | LEU858 |
A | LEU862 |
A | GLU865 |
A | HOH1272 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue MG B 1101 |
Chain | Residue |
B | ASN842 |
B | ASP855 |
B | ANP1102 |
site_id | AC5 |
Number of Residues | 19 |
Details | binding site for residue ANP B 1102 |
Chain | Residue |
B | LEU718 |
B | GLY721 |
B | ALA722 |
B | VAL726 |
B | ALA743 |
B | LYS745 |
B | MET790 |
B | GLN791 |
B | MET793 |
B | ASP837 |
B | ARG841 |
B | ASN842 |
B | ASP855 |
B | MG1101 |
B | JBJ1103 |
B | HOH1239 |
B | HOH1242 |
B | HOH1250 |
B | HOH1262 |
site_id | AC6 |
Number of Residues | 15 |
Details | binding site for residue JBJ B 1103 |
Chain | Residue |
B | VAL726 |
B | ALA743 |
B | LYS745 |
B | ILE759 |
B | CYS775 |
B | ARG776 |
B | LEU777 |
B | LEU788 |
B | MET790 |
B | ASP855 |
B | PHE856 |
B | LEU858 |
B | LEU861 |
B | LEU862 |
B | ANP1102 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue MG C 1101 |
Chain | Residue |
C | ASN842 |
C | ASP855 |
C | ANP1102 |
site_id | AC8 |
Number of Residues | 21 |
Details | binding site for residue ANP C 1102 |
Chain | Residue |
C | GLN791 |
C | LEU792 |
C | MET793 |
C | ASP837 |
C | ARG841 |
C | ASN842 |
C | LEU844 |
C | ASP855 |
C | MG1101 |
C | JBJ1103 |
C | HOH1218 |
C | HOH1221 |
C | HOH1238 |
C | LEU718 |
C | GLY721 |
C | ALA722 |
C | GLY724 |
C | VAL726 |
C | ALA743 |
C | LYS745 |
C | MET790 |
site_id | AC9 |
Number of Residues | 14 |
Details | binding site for residue JBJ C 1103 |
Chain | Residue |
C | ALA743 |
C | ILE744 |
C | LYS745 |
C | MET766 |
C | ARG776 |
C | LEU777 |
C | LEU788 |
C | MET790 |
C | ASP855 |
C | PHE856 |
C | LEU858 |
C | LEU861 |
C | ANP1102 |
C | HOH1213 |
site_id | AD1 |
Number of Residues | 3 |
Details | binding site for residue MG D 1101 |
Chain | Residue |
D | ASN842 |
D | ASP855 |
D | ANP1102 |
site_id | AD2 |
Number of Residues | 28 |
Details | binding site for residue ANP D 1102 |
Chain | Residue |
D | GLY719 |
D | SER720 |
D | GLY721 |
D | ALA722 |
D | GLY724 |
D | VAL726 |
D | ALA743 |
D | LYS745 |
D | MET790 |
D | GLN791 |
D | LEU792 |
D | MET793 |
D | ASP800 |
D | ASP837 |
D | ARG841 |
D | ASN842 |
D | LEU844 |
D | ASP855 |
D | MG1101 |
D | JBJ1103 |
D | HOH1212 |
D | HOH1233 |
D | HOH1244 |
D | HOH1255 |
D | HOH1257 |
D | HOH1280 |
D | HOH1292 |
D | HOH1300 |
site_id | AD3 |
Number of Residues | 15 |
Details | binding site for residue JBJ D 1103 |
Chain | Residue |
D | PHE723 |
D | ALA743 |
D | LYS745 |
D | LEU747 |
D | MET766 |
D | ARG776 |
D | LEU777 |
D | LEU788 |
D | MET790 |
D | ASP855 |
D | PHE856 |
D | LEU858 |
D | LEU861 |
D | GLU865 |
D | ANP1102 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue MG E 1101 |
Chain | Residue |
E | ASN842 |
E | ASP855 |
E | ANP1102 |
site_id | AD5 |
Number of Residues | 25 |
Details | binding site for residue ANP E 1102 |
Chain | Residue |
E | GLY719 |
E | SER720 |
E | GLY721 |
E | ALA722 |
E | GLY724 |
E | VAL726 |
E | ALA743 |
E | LYS745 |
E | MET790 |
E | GLN791 |
E | LEU792 |
E | MET793 |
E | ASP837 |
E | ARG841 |
E | ASN842 |
E | LEU844 |
E | ASP855 |
E | MG1101 |
E | JBJ1103 |
E | HOH1217 |
E | HOH1234 |
E | HOH1236 |
E | HOH1241 |
E | HOH1255 |
E | HOH1273 |
site_id | AD6 |
Number of Residues | 16 |
Details | binding site for residue JBJ E 1103 |
Chain | Residue |
E | ALA743 |
E | ILE744 |
E | LYS745 |
E | LEU747 |
E | MET766 |
E | CYS775 |
E | ARG776 |
E | LEU777 |
E | LEU788 |
E | MET790 |
E | ASP855 |
E | PHE856 |
E | LEU858 |
E | LEU861 |
E | LEU862 |
E | ANP1102 |
site_id | AD7 |
Number of Residues | 3 |
Details | binding site for residue MG F 1101 |
Chain | Residue |
F | ASN842 |
F | ASP855 |
F | ANP1102 |
site_id | AD8 |
Number of Residues | 21 |
Details | binding site for residue ANP F 1102 |
Chain | Residue |
F | LEU718 |
F | SER720 |
F | GLY721 |
F | ALA722 |
F | GLY724 |
F | VAL726 |
F | ALA743 |
F | LYS745 |
F | MET790 |
F | GLN791 |
F | MET793 |
F | ASP837 |
F | ARG841 |
F | ASN842 |
F | LEU844 |
F | ASP855 |
F | MG1101 |
F | JBJ1103 |
F | HOH1202 |
F | HOH1235 |
F | HOH1244 |
site_id | AD9 |
Number of Residues | 13 |
Details | binding site for residue JBJ F 1103 |
Chain | Residue |
F | ALA743 |
F | LYS745 |
F | GLU749 |
F | ILE759 |
F | MET766 |
F | ARG776 |
F | LEU777 |
F | LEU788 |
F | MET790 |
F | ASP855 |
F | PHE856 |
F | LEU858 |
F | ANP1102 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 28 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGTVYkGlwipegekvkip......VAIK |
Chain | Residue | Details |
A | LEU718-LYS745 | |
site_id | PS00109 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNVLV |
Chain | Residue | Details |
A | LEU833-VAL845 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASP837 | |
B | ASP837 | |
C | ASP837 | |
D | ASP837 | |
E | ASP837 | |
F | ASP837 | |
Chain | Residue | Details |
A | LEU718 | |
B | LEU718 | |
C | LEU718 | |
D | LEU718 | |
E | LEU718 | |
F | LEU718 | |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 |
Chain | Residue | Details |
A | LYS745 | |
B | LYS745 | |
C | LYS745 | |
D | LYS745 | |
E | LYS745 | |
F | LYS745 | |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:3VJO, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 |
Chain | Residue | Details |
A | MET790 | |
B | MET790 | |
C | MET790 | |
D | MET790 | |
E | MET790 | |
F | MET790 | |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17349580, ECO:0000269|PubMed:19563760, ECO:0007744|PDB:2EB3, ECO:0007744|PDB:2GS7, ECO:0007744|PDB:2ITN, ECO:0007744|PDB:2ITV, ECO:0007744|PDB:2ITX, ECO:0007744|PDB:3GT8, ECO:0007744|PDB:3VJN, ECO:0007744|PDB:4RIW, ECO:0007744|PDB:4RIX, ECO:0007744|PDB:4RIY, ECO:0007744|PDB:4ZSE, ECO:0007744|PDB:5CNN, ECO:0007744|PDB:5CNO, ECO:0007744|PDB:5D41 |
Chain | Residue | Details |
A | ASP855 | |
B | ASP855 | |
C | ASP855 | |
D | ASP855 | |
E | ASP855 | |
F | ASP855 | |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | SITE: Important for interaction with PIK3C2B |
Chain | Residue | Details |
A | TYR1016 | |
B | TYR1016 | |
C | TYR1016 | |
D | TYR1016 | |
E | TYR1016 | |
F | TYR1016 | |
Chain | Residue | Details |
A | SER695 | |
B | SER695 | |
C | SER695 | |
D | SER695 | |
E | SER695 | |
F | SER695 | |
Chain | Residue | Details |
A | LYS745 | |
B | LYS745 | |
C | LYS745 | |
D | LYS745 | |
E | LYS745 | |
F | LYS745 | |
Chain | Residue | Details |
A | TYR869 | |
B | TYR869 | |
C | TYR869 | |
D | TYR869 | |
E | TYR869 | |
F | TYR869 | |
Chain | Residue | Details |
A | SER991 | |
B | SER991 | |
C | SER991 | |
D | SER991 | |
E | SER991 | |
F | SER991 | |
Chain | Residue | Details |
A | SER995 | |
B | SER995 | |
C | SER995 | |
D | SER995 | |
E | SER995 | |
F | SER995 | |
Chain | Residue | Details |
A | TYR998 | |
B | TYR998 | |
C | TYR998 | |
D | TYR998 | |
E | TYR998 | |
F | TYR998 | |
Chain | Residue | Details |
A | TYR1016 | |
B | TYR1016 | |
C | TYR1016 | |
D | TYR1016 | |
E | TYR1016 | |
F | TYR1016 | |
Chain | Residue | Details |
A | LYS716 | |
C | LYS737 | |
C | LYS754 | |
C | LYS867 | |
D | LYS716 | |
D | LYS737 | |
D | LYS754 | |
D | LYS867 | |
E | LYS716 | |
E | LYS737 | |
E | LYS754 | |
A | LYS737 | |
E | LYS867 | |
F | LYS716 | |
F | LYS737 | |
F | LYS754 | |
F | LYS867 | |
A | LYS754 | |
A | LYS867 | |
B | LYS716 | |
B | LYS737 | |
B | LYS754 | |
B | LYS867 | |
C | LYS716 | |
site_id | SWS_FT_FI15 |
Number of Residues | 18 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144 |
Chain | Residue | Details |
D | LYS929 | |
D | LYS970 | |
E | LYS929 | |
E | LYS970 | |
F | LYS929 | |
F | LYS970 | |
A | LYS929 | |
A | LYS970 | |
B | LYS929 | |
B | LYS970 | |
C | LYS929 | |
C | LYS970 | |
site_id | SWS_FT_FI16 |
Number of Residues | 12 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33996800 |
Chain | Residue | Details |
A | LYS757 | |
E | LYS960 | |
F | LYS757 | |
F | LYS960 | |
A | LYS960 | |
B | LYS757 | |
B | LYS960 | |
C | LYS757 | |
C | LYS960 | |
D | LYS757 | |
D | LYS960 | |
E | LYS757 | |