6DUK
EGFR with an allosteric inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Epidermal growth factor receptor | polymer | 331 | 37724.6 | 6 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | G, J, M, P, S... (A, B, C, D, E...) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 3 | H, K, N, Q, T... (A, B, C, D, E...) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 6 | Chemie (ANP) | |||
| 4 | I, L, O, R, U... (A, B, C, D, E...) | (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide | non-polymer | 543.6 | 6 | Chemie (JBJ) | |||
| 5 | AA, BA, CA, DA, Y... (C, D, E, F, A...) | water | water | 18.0 | 644 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 692 | - | expression tag |
| Ser 693 | - | expression tag |
| Thr 694 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 226347.6 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 6444.7 | |
| All* | Total formula weight | 232792.3 |
