5CI6
 
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5JUR
 | | PB2 bound to an azaindole inhibitor | | 分子名称: | (3~{R})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-4,4-dimethyl-pentanoic acid, Polymerase basic protein 2 | | 著者 | Jacobs, M.D. | | 登録日 | 2016-05-10 | | 公開日 | 2017-03-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | | 主引用文献 | Discovery of Novel, Orally Bioavailable beta-Amino Acid Azaindole Inhibitors of Influenza PB2.
ACS Med Chem Lett, 8, 2017
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2OA5
 | | Crystal structure of ORF52 from Murid herpesvirus (MUHV-4) (Murine gammaherpesvirus 68) at 2.1 A resolution. Northeast Structural Genomics Consortium target MHR28B. | | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Hypothetical protein BQLF2 | | 著者 | Benach, J, Chen, Y, Seetharaman, J, Janjua, H, Xiao, R, Cunningham, K, Ma, L.-C, Ho, C.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2006-12-14 | | 公開日 | 2007-01-30 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and functional studies of the abundant tegument protein ORF52 from murine gammaherpesvirus 68.
J.Biol.Chem., 282, 2007
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4IKP
 | | Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin | | 分子名称: | (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, GLYCEROL, Histone-arginine methyltransferase CARM1, ... | | 著者 | Dong, A, Dombrovski, L, He, H, Ibanez, G, Wernimont, A, Zheng, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Luo, M, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2012-12-27 | | 公開日 | 2013-02-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.
Elife, 8, 2019
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4C13
 | | x-ray crystal structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Ruane, K.M, Roper, D.I, Fulop, V, Barreteau, H, Boniface, A, Dementin, S, Blanot, D, Mengin-Lecreulx, D, Gobec, S, Dessen, A, Dowson, C.G, Lloyd, A.J. | | 登録日 | 2013-08-09 | | 公開日 | 2013-10-02 | | 最終更新日 | 2021-03-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy.
Nat.Chem.Biol., 2021
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2I4T
 | | Crystal structure of Purine Nucleoside Phosphorylase from Trichomonas vaginalis with Imm-A | | 分子名称: | 3,4-PYRROLIDINEDIOL,2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)-2S,3S,4R,5R, PHOSPHATE ION, Trichomonas vaginalis purine nucleoside phosphorylase | | 著者 | Rinaldo-Matthis, A, Schramm, V.L, Almo, S.C. | | 登録日 | 2006-08-22 | | 公開日 | 2007-06-05 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | | 主引用文献 | Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues.
Biochemistry, 46, 2007
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2ISC
 | | Crystal structure of Purine Nucleoside Phosphorylase from Trichomonas vaginalis with DADMe-Imm-A | | 分子名称: | (3R,4R)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-(HYDROXYMETHYL)PYRROLIDIN-3-OL, PHOSPHATE ION, purine nucleoside phosphorylase | | 著者 | Rinaldo-Matthis, A, Almo, S.C, Schramm, V.L. | | 登録日 | 2006-10-17 | | 公開日 | 2007-06-05 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues
Biochemistry, 46, 2007
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5HGU
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2LWF
 | | Structure of N-terminal domain of a plant Grx | | 分子名称: | Monothiol glutaredoxin-S16, chloroplastic | | 著者 | Feng, Y. | | 登録日 | 2012-07-28 | | 公開日 | 2013-05-22 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural insights into the N-terminal GIY-YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts.
Proc.Natl.Acad.Sci.USA, 110, 2013
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3LT3
 | | Crystal structure of Rv3671c from M. tuberculosis H37Rv, Ser343Ala mutant, inactive form | | 分子名称: | POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE | | 著者 | Biswas, T, Small, J, Vandal, O, Ehrt, S, Tsodikov, O.V. | | 登録日 | 2010-02-14 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.
Structure, 18, 2010
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3J3W
 | | Atomic model of the immature 50S subunit from Bacillus subtilis (state II-a) | | 分子名称: | 50S ribosomal protein L1, 50S ribosomal protein L11, 50S ribosomal protein L13, ... | | 著者 | Li, N, Guo, Q, Zhang, Y, Yuan, Y, Ma, C, Lei, J, Gao, N. | | 登録日 | 2013-04-28 | | 公開日 | 2013-06-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (10.7 Å) | | 主引用文献 | Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit
Nucleic Acids Res., 41, 2013
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3K6Y
 | | Crystal structure of Rv3671c protease from M. tuberculosis, active form | | 分子名称: | POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE | | 著者 | Biswas, T, Small, J, Vandal, O, Ehrt, S, Tsodikov, O.V. | | 登録日 | 2009-10-10 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.
Structure, 18, 2010
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3J3V
 | | Atomic model of the immature 50S subunit from Bacillus subtilis (state I-a) | | 分子名称: | 50S ribosomal protein L1, 50S ribosomal protein L11, 50S ribosomal protein L13, ... | | 著者 | Li, N, Guo, Q, Zhang, Y, Yuan, Y, Ma, C, Lei, J, Gao, N. | | 登録日 | 2013-04-28 | | 公開日 | 2013-06-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (13.3 Å) | | 主引用文献 | Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit
Nucleic Acids Res., 41, 2013
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3U96
 | | Crystal Structure of YopHQ357F(Catalytic Domain, Residues 163-468) in complex with pNCS | | 分子名称: | N,4-DIHYDROXY-N-OXO-3-(SULFOOXY)BENZENAMINIUM, SULFATE ION, Tyrosine-protein phosphatase yopH | | 著者 | Ho, M.C, Ke, S. | | 登録日 | 2011-10-17 | | 公開日 | 2012-08-29 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Investigation of catalytic loop structure, dynamics, and function relationship of Yersinia protein tyrosine phosphatase by temperature-jump relaxation spectroscopy and X-ray structural determination.
J.Phys.Chem.B, 116, 2012
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5YGI
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4Z0V
 | | The structure of human PDE12 residues 161-609 | | 分子名称: | 2',5'-phosphodiesterase 12, GLYCEROL, MAGNESIUM ION | | 著者 | Nolte, R.T, Wisely, B, Wang, L, Wood, E.R. | | 登録日 | 2015-03-26 | | 公開日 | 2015-06-17 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
J.Biol.Chem., 290, 2015
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4Z2B
 | | The structure of human PDE12 residues 161-609 in complex with GSK3036342A | | 分子名称: | 1,2-ETHANEDIOL, 2',5'-phosphodiesterase 12, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Nolte, R.T, Wisely, B, Wang, L, Wood, E.R. | | 登録日 | 2015-03-29 | | 公開日 | 2015-06-17 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
J.Biol.Chem., 290, 2015
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4NCE
 | | Influenza polymerase basic protein 2 (PB2) bound to 7-methyl-GTP | | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, 9,10-dioxo-9,10-dihydroanthracene-2,6-disulfonic acid, Polymerase basic protein 2 | | 著者 | Jacobs, M.D. | | 登録日 | 2013-10-24 | | 公開日 | 2014-07-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2.
J.Med.Chem., 57, 2014
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4NCM
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4P1U
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7EPM
 | | human LDHC complexed with NAD+ and ethylamino acetic acid | | 分子名称: | 2-(ethylamino)-2-oxidanylidene-ethanoic acid, L-lactate dehydrogenase C chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Yu, Y, Chen, Q. | | 登録日 | 2021-04-27 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Identification of human LDHC4 as a potential target for anticancer drug discovery.
Acta Pharm Sin B, 12, 2022
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3K6Z
 | | Crystal structure of Rv3671c protease, inactive form | | 分子名称: | POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE | | 著者 | Biswas, T, Small, J, Vandal, O, Ehrt, S, Tsodikov, O.V. | | 登録日 | 2009-10-10 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.
Structure, 18, 2010
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5YIJ
 | | Structure of a Legionella effector with substrates | | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, SdeA, Ubiquitin | | 著者 | Feng, Y, Mu, Y, Wang, H. | | 登録日 | 2017-10-05 | | 公開日 | 2018-05-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | | 主引用文献 | Structural basis of ubiquitin modification by the Legionella effector SdeA.
Nature, 557, 2018
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4GIW
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5HZG
 | | The crystal structure of the strigolactone-induced AtD14-D3-ASK1 complex | | 分子名称: | (2Z)-2-methylbut-2-ene-1,4-diol, F-box/LRR-repeat MAX2 homolog, SKP1-like protein 1A, ... | | 著者 | Yao, R.F, Ming, Z.H, Yan, L.M, Rao, Z.H, Lou, Z.Y, Xie, D.X. | | 登録日 | 2016-02-02 | | 公開日 | 2016-08-03 | | 最終更新日 | 2016-08-31 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | DWARF14 is a non-canonical hormone receptor for strigolactone
Nature, 536, 2016
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