4Z0V

The structure of human PDE12 residues 161-609

Summary for 4Z0V

Entry DOI	10.2210/pdb4z0v/pdb
Related	4Z2B
Descriptor	2',5'-phosphodiesterase 12, MAGNESIUM ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	pde12 2'-5'a eep nuclease, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Mitochondrion matrix : Q6L8Q7
Total number of polymer chains	1
Total formula weight	50233.98
Authors	Nolte, R.T.,Wisely, B.,Wang, L.,Wood, E.R. (deposition date: 2015-03-26, release date: 2015-06-17, Last modification date: 2023-09-27)
Primary citation	Wood, E.R.,Bledsoe, R.,Chai, J.,Daka, P.,Deng, H.,Ding, Y.,Harris-Gurley, S.,Kryn, L.H.,Nartey, E.,Nichols, J.,Nolte, R.T.,Prabhu, N.,Rise, C.,Sheahan, T.,Shotwell, J.B.,Smith, D.,Tai, V.,Taylor, J.D.,Tomberlin, G.,Wang, L.,Wisely, B.,You, S.,Xia, B.,Dickson, H. The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. J.Biol.Chem., 290:19681-19696, 2015 Cited by PubMed: 26055709 DOI: 10.1074/jbc.M115.653113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation