4Z0V

The structure of human PDE12 residues 161-609

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 701

Chain	Residue
A	GLU351
A	HOH809
A	HOH824
A	HOH848
A	HOH1008
A	HOH1031

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site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 702

Chain	Residue
A	GLY255
A	ARG257
A	PHE258
A	HOH807
A	SER192
A	GLY253
A	ASP254

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site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 703

Chain	Residue
A	GLN396
A	HIS397
A	ASP398
A	HOH861
A	HOH876
A	HOH904

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site_id	AC4
Number of Residues	2
Details	binding site for residue GOL A 704

Chain	Residue
A	LEU393
A	GLN396

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site_id	AC5
Number of Residues	3
Details	binding site for residue GOL A 705

Chain	Residue
A	ASN568
A	LYS609
A	HOH803

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site_id	AC6
Number of Residues	5
Details	binding site for residue GOL A 706

Chain	Residue
A	TRP459
A	PRO461
A	ARG467
A	ASN498
A	HOH1047

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site_id	AC7
Number of Residues	4
Details	binding site for residue GOL A 707

Chain	Residue
A	LYS417
A	LEU534
A	THR535
A	HOH922

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:Q96LI5

Chain	Residue	Details
A	ASN511

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:26055709, ECO:0000269|Ref.16, ECO:0007744|PDB:4Z0V, ECO:0007744|PDB:4ZKF

Chain	Residue	Details
A	GLU366

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|Ref.16, ECO:0007744|PDB:4ZKF

Chain	Residue	Details
A	ASN511
A	SER513

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	GLU232

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