4NCM

Influenza polymerase basic protein 2 (PB2) bound to a small-molecule inhibitor

Summary for 4NCM

• Entry DOI: 10.2210/pdb4ncm/pdb
• Related: 4NCE
• Descriptor: Polymerase basic protein 2, N~2~-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-N,N-dimethyl-L-alaninamide (3 entities in total)
• Functional Keywords: rna-dependent rna polymerase, transcription, pb2 subunit, influenza virus, cap-binding domain, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• Biological source: Influenza A virus
• Cellular location: Virion: P31345
• Total number of polymer chains: 1
• Total formula weight: 19537.11

Authors

Jacobs, M.D. (deposition date: 2013-10-24, release date: 2014-07-30, Last modification date: 2023-09-20)

• Primary citation: Clark, M.P.,Ledeboer, M.W.,Davies, I.,Byrn, R.A.,Jones, S.M.,Perola, E.,Tsai, A.,Jacobs, M.,Nti-Addae, K.,Bandarage, U.K.,Boyd, M.J.,Bethiel, R.S.,Court, J.J.,Deng, H.,Duffy, J.P.,Dorsch, W.A.,Farmer, L.J.,Gao, H.,Gu, W.,Jackson, K.,Jacobs, D.H.,Kennedy, J.M.,Ledford, B.,Liang, J.,Maltais, F.,Murcko, M.,Wang, T.,Wannamaker, M.W.,Bennett, H.B.,Leeman, J.R.,McNeil, C.,Taylor, W.P.,Memmott, C.,Jiang, M.,Rijnbrand, R.,Bral, C.,Germann, U.,Nezami, A.,Zhang, Y.,Salituro, F.G.,Bennani, Y.L.,Charifson, P.S.; Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2.; J.Med.Chem., 57:6668-6678, 2014; PubMed: 25019388; DOI: 10.1021/jm5007275

Experimental method

X-RAY DIFFRACTION (2.82 Å)