5YGI

Crystal structure of human FPPS in complex with an inhibitor THZ93

Summary for 5YGI

• Entry DOI: 10.2210/pdb5ygi/pdb
• Descriptor: Farnesyl pyrophosphate synthase, PHOSPHATE ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: thz93, complex, human fpps, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 40660.81

Authors

Li, X. (deposition date: 2017-09-23, release date: 2018-09-26, Last modification date: 2024-03-27)

• Primary citation: Xia, Y.,Xie, Y.,Yu, Z.,Xiao, H.,Jiang, G.,Zhou, X.,Yang, Y.,Li, X.,Zhao, M.,Li, L.,Zheng, M.,Han, S.,Zong, Z.,Meng, X.,Deng, H.,Ye, H.,Fa, Y.,Wu, H.,Oldfield, E.,Hu, X.,Liu, W.,Shi, Y.,Zhang, Y.; The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.; Cell, 175:1059-1073.e21, 2018; PubMed: 30270039; DOI: 10.1016/j.cell.2018.08.070

Experimental method

X-RAY DIFFRACTION (2.177 Å)