4Z2B

The structure of human PDE12 residues 161-609 in complex with GSK3036342A

Summary for 4Z2B

• Entry DOI: 10.2210/pdb4z2b/pdb
• Related: 4Z0V
• Descriptor: 2',5'-phosphodiesterase 12, SULFATE ION, 1,2-ETHANEDIOL, ... (7 entities in total)
• Functional Keywords: pde12 2'-5'a eep nuclease inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Mitochondrion matrix : Q6L8Q7
• Total number of polymer chains: 1
• Total formula weight: 51995.86

Authors

Nolte, R.T.,Wisely, B.,Wang, L.,Wood, E.R. (deposition date: 2015-03-29, release date: 2015-06-17, Last modification date: 2023-09-27)

• Primary citation: Wood, E.R.,Bledsoe, R.,Chai, J.,Daka, P.,Deng, H.,Ding, Y.,Harris-Gurley, S.,Kryn, L.H.,Nartey, E.,Nichols, J.,Nolte, R.T.,Prabhu, N.,Rise, C.,Sheahan, T.,Shotwell, J.B.,Smith, D.,Tai, V.,Taylor, J.D.,Tomberlin, G.,Wang, L.,Wisely, B.,You, S.,Xia, B.,Dickson, H.; The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.; J.Biol.Chem., 290:19681-19696, 2015; PubMed: 26055709; DOI: 10.1074/jbc.M115.653113

Experimental method

X-RAY DIFFRACTION (1.8 Å)