4Z2B

The structure of human PDE12 residues 161-609 in complex with GSK3036342A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue SO4 A 701

Chain	Residue
A	GLU207
A	LYS377
A	ARG431
A	SER432
A	TYR458
A	EDO702
A	HOH822
A	HOH843
A	HOH893

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site_id	AC2
Number of Residues	7
Details	binding site for residue EDO A 702

Chain	Residue
A	LYS377
A	SER433
A	HIS456
A	LEU457
A	TYR458
A	TRP459
A	SO4701

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 703

Chain	Residue
A	PHE177
A	PRO274
A	GLY275
A	CYS277
A	ASP280
A	LYS337

---

site_id	AC4
Number of Residues	9
Details	binding site for residue TRS A 704

Chain	Residue
A	HIS281
A	LYS412
A	GLU416
A	SER580
A	GLU583
A	HOH818
A	HOH857
A	HOH936
A	HOH1037

---

site_id	AC5
Number of Residues	19
Details	binding site for residue 4LC A 705

Chain	Residue
A	PRO208
A	GLU209
A	TYR307
A	THR310
A	SER313
A	GLU351
A	TRP459
A	PRO461
A	ASN498
A	SER499
A	THR500
A	THR503
A	PHE556
A	MG706
A	HOH842
A	HOH844
A	HOH920
A	HOH973
A	HOH1098

---

site_id	AC6
Number of Residues	6
Details	binding site for residue MG A 706

Chain	Residue
A	GLU351
A	ASP598
A	4LC705
A	HOH828
A	HOH847
A	HOH1038

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:Q96LI5

Chain	Residue	Details
A	ASP496

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:26055709, ECO:0000269|Ref.16, ECO:0007744|PDB:4Z0V, ECO:0007744|PDB:4ZKF

Chain	Residue	Details
A	GLU351

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|Ref.16, ECO:0007744|PDB:4ZKF

Chain	Residue	Details
A	ASP496
A	ASN498

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER217

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