4Z2B
The structure of human PDE12 residues 161-609 in complex with GSK3036342A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 701 |
| Chain | Residue |
| A | GLU207 |
| A | LYS377 |
| A | ARG431 |
| A | SER432 |
| A | TYR458 |
| A | EDO702 |
| A | HOH822 |
| A | HOH843 |
| A | HOH893 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 702 |
| Chain | Residue |
| A | LYS377 |
| A | SER433 |
| A | HIS456 |
| A | LEU457 |
| A | TYR458 |
| A | TRP459 |
| A | SO4701 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 703 |
| Chain | Residue |
| A | PHE177 |
| A | PRO274 |
| A | GLY275 |
| A | CYS277 |
| A | ASP280 |
| A | LYS337 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue TRS A 704 |
| Chain | Residue |
| A | HIS281 |
| A | LYS412 |
| A | GLU416 |
| A | SER580 |
| A | GLU583 |
| A | HOH818 |
| A | HOH857 |
| A | HOH936 |
| A | HOH1037 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue 4LC A 705 |
| Chain | Residue |
| A | PRO208 |
| A | GLU209 |
| A | TYR307 |
| A | THR310 |
| A | SER313 |
| A | GLU351 |
| A | TRP459 |
| A | PRO461 |
| A | ASN498 |
| A | SER499 |
| A | THR500 |
| A | THR503 |
| A | PHE556 |
| A | MG706 |
| A | HOH842 |
| A | HOH844 |
| A | HOH920 |
| A | HOH973 |
| A | HOH1098 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 706 |
| Chain | Residue |
| A | GLU351 |
| A | ASP598 |
| A | 4LC705 |
| A | HOH828 |
| A | HOH847 |
| A | HOH1038 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 11 |
| Details | Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q96LI5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26055709","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2015","submissionDatabase":"PDB data bank","title":"Crystal structure of human phosphodiesterase.","authors":["Kim S.Y.","Kohno T.","Mori T.","Kitano K.","Hakoshima T."]}},{"source":"PDB","id":"4Z0V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZKF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2015","submissionDatabase":"PDB data bank","title":"Crystal structure of human phosphodiesterase.","authors":["Kim S.Y.","Kohno T.","Mori T.","Kitano K.","Hakoshima T."]}},{"source":"PDB","id":"4ZKF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
