4C13

x-ray crystal structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys

Summary for 4C13

Entry DOI	10.2210/pdb4c13/pdb
Related	4C12
Related PRD ID	PRD_002099
Descriptor	UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--L-LYSINE LIGASE, CHLORIDE ION, MAGNESIUM ION, ... (7 entities in total)
Functional Keywords	ligase, mure
Biological source	STAPHYLOCOCCUS AUREUS
Total number of polymer chains	1
Total formula weight	56508.38
Authors	Ruane, K.M.,Roper, D.I.,Fulop, V.,Barreteau, H.,Boniface, A.,Dementin, S.,Blanot, D.,Mengin-Lecreulx, D.,Gobec, S.,Dessen, A.,Dowson, C.G.,Lloyd, A.J. (deposition date: 2013-08-09, release date: 2013-10-02, Last modification date: 2021-03-17)
Primary citation	Wang, L.,Shao, X.,Zhong, T.,Wu, Y.,Xu, A.,Sun, X.,Gao, H.,Liu, Y.,Lan, T.,Tong, Y.,Tao, X.,Du, W.,Wang, W.,Chen, Y.,Li, T.,Meng, X.,Deng, H.,Yang, B.,He, Q.,Ying, M.,Rao, Y. Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy. Nat.Chem.Biol., 2021 Cited by PubMed: 33664520 DOI: 10.1038/s41589-021-00742-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation