4XNW
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![BU of 4xnw by Molmil](/molmil-images/mine/4xnw) | The human P2Y1 receptor in complex with MRS2500 | 分子名称: | P2Y purinoceptor 1,Rubredoxin,P2Y purinoceptor 1, ZINC ION, [(1R,2S,4S,5S)-4-[2-iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hex-1-yl]methyl dihydrogen phosphate | 著者 | Zhang, D, Gao, Z, Jacobson, K, Han, G.W, Stevens, R, Zhao, Q, Wu, B, GPCR Network (GPCR) | 登録日 | 2015-01-16 | 公開日 | 2015-04-01 | 最終更新日 | 2020-02-05 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Two disparate ligand-binding sites in the human P2Y1 receptor Nature, 520, 2015
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5YK1
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5YK2
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4XNV
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![BU of 4xnv by Molmil](/molmil-images/mine/4xnv) | The human P2Y1 receptor in complex with BPTU | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-[2-(2-tert-butylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethoxy)phenyl]urea, CHOLESTEROL, ... | 著者 | Zhang, D, Gao, Z, Jacobson, K, Han, G.W, Stevens, R, Zhao, Q, Wu, B, GPCR Network (GPCR) | 登録日 | 2015-01-16 | 公開日 | 2015-04-01 | 最終更新日 | 2020-02-05 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Two disparate ligand-binding sites in the human P2Y1 receptor Nature, 520, 2015
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5YK0
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4AI5
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![BU of 4ai5 by Molmil](/molmil-images/mine/4ai5) | |
4AI4
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4JZR
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![BU of 4jzr by Molmil](/molmil-images/mine/4jzr) | Structure of Prolyl Hydroxylase Domain-containing Protein (PHD) with Inhibitors | 分子名称: | 1,2-ETHANEDIOL, 2-(biphenyl-4-yl)-8-[(1-methyl-1H-imidazol-2-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one, Egl nine homolog 1, ... | 著者 | Ma, Y, Yang, L. | 登録日 | 2013-04-03 | 公開日 | 2013-10-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors Bioorg.Med.Chem., 21, 2013
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4Z6G
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![BU of 4z6g by Molmil](/molmil-images/mine/4z6g) | Structure of NT domain | 分子名称: | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5, PHOSPHATE ION | 著者 | Yang, F, Zhang, Y. | 登録日 | 2015-04-05 | 公開日 | 2016-04-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.654 Å) | 主引用文献 | In vivo epidermal migration requires focal adhesion targeting of ACF7. Nat Commun, 7, 2016
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4B7C
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![BU of 4b7c by Molmil](/molmil-images/mine/4b7c) | Crystal structure of hypothetical protein PA1648 from Pseudomonas aeruginosa. | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PROBABLE OXIDOREDUCTASE | 著者 | Alphey, M.S, McMahon, S.A, Duthie, F.G, Naismith, J.H. | 登録日 | 2012-08-17 | 公開日 | 2013-01-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery Acta Crystallogr.,Sect.F, 69, 2013
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8IL3
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![BU of 8il3 by Molmil](/molmil-images/mine/8il3) | Cryo-EM structure of CD38 in complex with FTL004 | 分子名称: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Heavy chain, Light chain | 著者 | Yang, J, Wang, Y, Zhang, G. | 登録日 | 2023-03-01 | 公開日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | 主引用文献 | FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma. J Hematol Oncol, 15, 2022
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4B9A
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![BU of 4b9a by Molmil](/molmil-images/mine/4b9a) | Structure of a putative epoxide hydrolase from Pseudomonas aeruginosa. | 分子名称: | GLYCEROL, PROBABLE EPOXIDE HYDROLASE, SULFATE ION | 著者 | Schmidberger, J.W, Schnell, R, Schneider, G. | 登録日 | 2012-09-03 | 公開日 | 2013-02-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery. Acta Crystallogr.,Sect.F, 69, 2013
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8HF8
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![BU of 8hf8 by Molmil](/molmil-images/mine/8hf8) | Human PPAR delta ligand binding domain in complex with a synthetic agonist V1 | 分子名称: | 2-[4-[[2,5-bis(oxidanylidene)-3-[4-(trifluoromethyl)phenyl]imidazolidin-1-yl]methyl]-2,6-dimethyl-phenoxy]-2-methyl-propanoic acid, Peroxisome proliferator-activated receptor delta, octyl beta-D-glucopyranoside | 著者 | Dai, L, Sun, H.B, Yuan, H.L, Feng, Z.Q. | 登録日 | 2022-11-09 | 公開日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Discovery of the First Subnanomolar PPAR alpha / delta Dual Agonist for the Treatment of Cholestatic Liver Diseases. J.Med.Chem., 66, 2023
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4B9E
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![BU of 4b9e by Molmil](/molmil-images/mine/4b9e) | Structure of a putative epoxide hydrolase from Pseudomonas aeruginosa, with bound MFA. | 分子名称: | GLYCEROL, PROBABLE EPOXIDE HYDROLASE, SULFATE ION, ... | 著者 | Schmidberger, J.W, Schnell, R, Schneider, G. | 登録日 | 2012-09-04 | 公開日 | 2013-02-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery. Acta Crystallogr.,Sect.F, 69, 2013
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4AIA
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4B7X
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![BU of 4b7x by Molmil](/molmil-images/mine/4b7x) | Crystal structure of hypothetical protein PA1648 from Pseudomonas aeruginosa. | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROBABLE OXIDOREDUCTASE | 著者 | Alphey, M.S, McMahon, S.A, Duthie, F, Naismith, J.H. | 登録日 | 2012-08-24 | 公開日 | 2013-01-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-Stage Drug Discovery Acta Crystallogr.,Sect.F, 69, 2013
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7EPC
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![BU of 7epc by Molmil](/molmil-images/mine/7epc) | Cryo-EM structure of inactive mGlu7 homodimer | 分子名称: | Isoform 3 of Metabotropic glutamate receptor 7 | 著者 | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | 登録日 | 2021-04-26 | 公開日 | 2021-06-23 | 最終更新日 | 2021-07-07 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature, 594, 2021
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7EPB
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![BU of 7epb by Molmil](/molmil-images/mine/7epb) | Cryo-EM structure of LY354740-bound mGlu2 homodimer | 分子名称: | (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, Anti-RON nanobody, Metabotropic glutamate receptor 2 | 著者 | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | 登録日 | 2021-04-26 | 公開日 | 2021-06-23 | 最終更新日 | 2021-07-07 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature, 594, 2021
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7EPA
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![BU of 7epa by Molmil](/molmil-images/mine/7epa) | Cryo-EM structure of inactive mGlu2 homodimer | 分子名称: | Metabotropic glutamate receptor 2 | 著者 | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | 登録日 | 2021-04-26 | 公開日 | 2021-06-23 | 最終更新日 | 2021-07-07 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature, 594, 2021
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7EPF
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![BU of 7epf by Molmil](/molmil-images/mine/7epf) | Crystal structure of mGlu2 bound to NAM597 | 分子名称: | (8~{R})-4-[2,4-bis(fluoranyl)phenyl]-8-methyl-7-[(2-methylpyrazol-3-yl)methyl]-6,8-dihydro-5~{H}-1,7-naphthyridine-2-carboxamide, FLAVIN MONONUCLEOTIDE, Metabotropic glutamate receptor 2 | 著者 | Du, J, Wang, D, Lin, S, Han, S, Wu, B, Zhao, Q. | 登録日 | 2021-04-26 | 公開日 | 2021-06-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature, 594, 2021
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7EPD
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![BU of 7epd by Molmil](/molmil-images/mine/7epd) | Cryo-EM structure of inactive mGlu2-7 heterodimer | 分子名称: | Isoform 3 of Metabotropic glutamate receptor 7, Metabotropic glutamate receptor 2,Peptidylprolyl isomerase | 著者 | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | 登録日 | 2021-04-26 | 公開日 | 2021-06-23 | 最終更新日 | 2021-07-07 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature, 594, 2021
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7EPE
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![BU of 7epe by Molmil](/molmil-images/mine/7epe) | Crystal structure of mGlu2 bound to NAM563 | 分子名称: | 4-(1-methylpyrazol-4-yl)-7-[[(2~{S})-2-(trifluoromethyl)morpholin-4-yl]methyl]quinoline-2-carboxamide, FLAVIN MONONUCLEOTIDE, Metabotropic glutamate receptor 2 | 著者 | Du, J, Wang, D, Lin, S, Han, S, Wu, B, Zhao, Q. | 登録日 | 2021-04-26 | 公開日 | 2021-06-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature, 594, 2021
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2HH5
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![BU of 2hh5 by Molmil](/molmil-images/mine/2hh5) | Crystal Structure of Cathepsin S in complex with a Zinc mediated non-covalent arylaminoethyl amide | 分子名称: | CHLORIDE ION, Cathepsin S, N-[(1R)-1-[(BENZYLSULFONYL)METHYL]-2-{[(1S)-1-METHYL-2-{[4-(TRIFLUOROMETHOXY)PHENYL]AMINO}ETHYL]AMINO}-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE, ... | 著者 | Spraggon, G, Hornsby, M, Lesley, S.A, Tully, D.C, Harris, J.L, Karenewsky, D.S. | 登録日 | 2006-06-27 | 公開日 | 2006-08-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers. Bioorg.Med.Chem.Lett., 16, 2006
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7XDI
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![BU of 7xdi by Molmil](/molmil-images/mine/7xdi) | Tail structure of bacteriophage SSV19 | 分子名称: | B210, C131, VP1, ... | 著者 | Liu, H.R, Chen, W.Y. | 登録日 | 2022-03-27 | 公開日 | 2022-08-10 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural insights into a spindle-shaped archaeal virus with a sevenfold symmetrical tail. Proc.Natl.Acad.Sci.USA, 119, 2022
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6FV2
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![BU of 6fv2 by Molmil](/molmil-images/mine/6fv2) | |