7EPF

Crystal structure of mGlu2 bound to NAM597

Summary for 7EPF

• Entry DOI: 10.2210/pdb7epf/pdb
• Descriptor: Metabotropic glutamate receptor 2, FLAVIN MONONUCLEOTIDE, (8~{R})-4-[2,4-bis(fluoranyl)phenyl]-8-methyl-7-[(2-methylpyrazol-3-yl)methyl]-6,8-dihydro-5~{H}-1,7-naphthyridine-2-carboxamide (3 entities in total)
• Functional Keywords: membrane protein, gpcr
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 49350.34

Authors

Du, J.,Wang, D.,Lin, S.,Han, S.,Wu, B.,Zhao, Q. (deposition date: 2021-04-26, release date: 2021-06-23, Last modification date: 2023-11-29)

• Primary citation: Du, J.,Wang, D.,Fan, H.,Xu, C.,Tai, L.,Lin, S.,Han, S.,Tan, Q.,Wang, X.,Xu, T.,Zhang, H.,Chu, X.,Yi, C.,Liu, P.,Wang, X.,Zhou, Y.,Pin, J.P.,Rondard, P.,Liu, H.,Liu, J.,Sun, F.,Wu, B.,Zhao, Q.; Structures of human mGlu2 and mGlu7 homo- and heterodimers.; Nature, 594:589-593, 2021; PubMed: 34135509; DOI: 10.1038/s41586-021-03641-w

Experimental method

X-RAY DIFFRACTION (2.7 Å)