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Crystal structure of Influenza B polymerase bound to the vRNA promoter (FluB1 form)
分子名称:	Influenza B vRNA promoter 3' end, Influenza B vRNA promoter 5' end, PA, ...
著者	Reich, S, Guilligay, D, Pflug, A, Cusack, S.
登録日	2014-10-26
公開日	2014-11-19
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (3.4 Å)
主引用文献	Structural insight into cap-snatching and RNA synthesis by influenza polymerase. Nature, 516, 2014

7Z4O

Influenza A/H7N9 polymerase core dimer with Pol II pSer5 CTD peptide mimic bound in site 2A
分子名称:	MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者	Cusack, S, Pflug, A.
登録日	2022-03-04
公開日	2022-05-11
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (3.412 Å)
主引用文献	Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD. Plos Pathog., 18, 2022

5FMM

crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza a virus polymerase PB2 subunit bound to M7GTP
分子名称:	7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, CITRATE ANION, INFLUENZA A PB2 SUBUNIT
著者	Thierry, E, Pflug, A, Hart, D, Cusack, S.
登録日	2015-11-06
公開日	2016-01-13
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains. Mol.Cell, 61, 2016

5FMQ

Crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza A virus polymerase PB2 subunit bound to M7GTP H32 crystal form
分子名称:	7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, INFLUENZA A PB2 SUBUNIT
著者	Thierry, E, Pflug, A, Hart, D, Cusack, S.
登録日	2015-11-07
公開日	2016-01-13
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains. Mol.Cell, 61, 2016

6TU5

Influenza A/H7N9 polymerase core (apo)
分子名称:	MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者	Cusack, S, Pflug, A.
登録日	2020-01-02
公開日	2020-04-15
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (3.325 Å)
主引用文献	A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020

7AW0

MerTK kinase domain in complex with purine inhibitor
分子名称:	2-(cyclopentyloxy)-9-(2,6-difluorobenzyl)-N-methyl-9H-purin-6-amine, Tyrosine-protein kinase Mer
著者	Schimpl, M, Nissink, J.W.M, Blackett, C, Clarke, M, Disch, J, Goldberg, K, Guilinger, J, Hennessy, E.J, Jetson, R, Ginkunja, D, Hardaker, E, Keefe, A, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S, Zhang, Y.
登録日	2020-11-06
公開日	2021-03-03
最終更新日	2024-05-01
実験手法	X-RAY DIFFRACTION (1.893 Å)
主引用文献	Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J.Med.Chem., 64, 2021

7AVY

MerTK kinase domain in complex with quinazoline-based inhbitor
分子名称:	N-(2-(2-cyclopropylethoxy)pyrimidin-5-yl)-7-methoxy-6-(piperidin-4-ylmethoxy)quinazolin-4-amine, SULFATE ION, Tyrosine-protein kinase Mer
著者	Schimpl, M, Nissink, J.W.M, Blackett, C, Goldberg, K, Hennessy, E.J, Hardaker, E, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S.
登録日	2020-11-06
公開日	2021-03-03
最終更新日	2024-05-01
実験手法	X-RAY DIFFRACTION (2.31 Å)
主引用文献	Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J.Med.Chem., 64, 2021

7AVX

MerTK kinase domain in complex with NPS-1034
分子名称:	1-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dimethyl-5-oxopyrazole-4-carboxamide, Tyrosine-protein kinase Mer
著者	Schimpl, M, Nissink, J.W.M, Blackett, C, Goldberg, K, Hennessy, E.J, Hardaker, E, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S.
登録日	2020-11-06
公開日	2021-03-03
最終更新日	2024-05-01
実験手法	X-RAY DIFFRACTION (2.44 Å)
主引用文献	Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J.Med.Chem., 64, 2021

7AW2

MerTK kinase domain with type 1.5 inhibitor from a DNA-encoded library
分子名称:	5-(2'-chloro-[1,1'-biphenyl]-4-yl)-N-(imidazo[1,2-a]pyridin-6-ylmethyl)-N-methyl-1,3,4-oxadiazol-2-amine, Tyrosine-protein kinase Mer
著者	Schimpl, M, Nissink, J.W.M, Blackett, C, Goldberg, K, Hennessy, E.J, Hardaker, E, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S.
登録日	2020-11-06
公開日	2021-03-03
最終更新日	2024-05-01
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J.Med.Chem., 64, 2021

7AW1

MerTK kinase domain in complex with a type 2 inhibitor
分子名称:	N-(6-(4-(3-(4-((5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide, Tyrosine-protein kinase Mer
著者	Schimpl, M, Nissink, J.W.M, Blackett, C, Goldberg, K, Hennessy, E.J, Hardaker, E, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S.
登録日	2020-11-06
公開日	2021-03-03
最終更新日	2024-05-01
実験手法	X-RAY DIFFRACTION (1.98 Å)
主引用文献	Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J.Med.Chem., 64, 2021

7AW3

MerTK kinase domain with type 1 inhibitor from a DNA-encoded library
分子名称:	2-(1-((5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxamido)methyl)-2-azabicyclo[2.1.1]hexan-2-yl)-N-methyl-4-(trifluoromethyl)thiazole-5-carboxamide, Tyrosine-protein kinase Mer
著者	Schimpl, M, Nissink, J.W.M, Blackett, C, Goldberg, K, Hennessy, E.J, Hardaker, E, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S.
登録日	2020-11-06
公開日	2021-03-03
最終更新日	2024-05-01
実験手法	X-RAY DIFFRACTION (1.99 Å)
主引用文献	Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J.Med.Chem., 64, 2021

6EUX

Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
分子名称:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2
著者	Cusack, S, Gaudon, S.
登録日	2017-10-31
公開日	2017-12-13
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

6EUV

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787)
分子名称:	(2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, Polymerase basic protein 2
著者	Cusack, S, Lethier, M.
登録日	2017-10-31
公開日	2017-12-13
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

6EUY

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
分子名称:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2, SULFATE ION
著者	Cusack, S, Gaudon, S.
登録日	2017-10-31
公開日	2017-12-13
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

6EUW

Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor
分子名称:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, Polymerase basic protein 2
著者	Cusack, S, Gaudon, S.
登録日	2017-10-31
公開日	2017-12-13
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1 Å)
主引用文献	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

7ZPL

Symmetric dimer of influenza A/H7N9 polymerase bound to 5' vRNA hook
分子名称:	5' vRNA, MAGNESIUM ION, Polymerase acidic protein, ...
著者	Cusack, S, Kouba, T.
登録日	2022-04-27
公開日	2022-12-28
最終更新日	2024-07-24
実験手法	ELECTRON MICROSCOPY (3.12 Å)
主引用文献	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

7ZPM

Influenza A/H7N9 polymerase apo-protein dimer complex
分子名称:	Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit
著者	Cusack, S, Kouba, T.
登録日	2022-04-27
公開日	2022-12-28
最終更新日	2024-07-24
実験手法	ELECTRON MICROSCOPY (2.81 Å)
主引用文献	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

5EPI

CRYSTAL STRUCTURE OF INFLUENZA B POLYMERASE WITH BOUND 5' CRNA EXHIBITS A NOVEL DOMAIN ARRANGEMENT
分子名称:	CRNA 5' END, Polymerase acidic protein, Polymerase basic protein 2, ...
著者	Guilligay, D, Cusack, S.
登録日	2015-11-11
公開日	2016-01-13
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (4.1 Å)
主引用文献	Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains. Mol.Cell, 61, 2016

5FMZ

Crystal structure of Influenza B polymerase with bound 5' vRNA
分子名称:	5'-R(APGPUPAPGPUPAPAPCPAPAPGP)-3', POLYMERASE ACIDIC PROTEIN, POLYMERASE BASIC PROTEIN 2, ...
著者	Guilligay, D, Cusack, S.
登録日	2015-11-10
公開日	2016-01-13
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (3.4 Å)
主引用文献	Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains. Mol.Cell, 61, 2016

5J5X

Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1416
分子名称:	4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine, 47P-AZ1-DAL-DAR-DAR-DAR-DAR, SULFATE ION, ...
著者	Alam, K.A, Ivan, T, Uri, A, Engh, R.A.
登録日	2016-04-04
公開日	2016-07-20
最終更新日	2019-06-19
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions. Bioconjug.Chem., 27, 2016

7QTL

Influenza A/H7N9 polymerase elongation complex
分子名称:	3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ...
著者	Cusack, S, Kouba, T.
登録日	2022-01-14
公開日	2022-12-28
最終更新日	2024-07-17
実験手法	ELECTRON MICROSCOPY (2.48 Å)
主引用文献	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

7R1F

Early transcription elongation state of influenza B polymerase backtracked due to double incoproation of nucleotide analogue T1106
分子名称:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者	Cusack, S, Kouba, T.
登録日	2022-02-02
公開日	2022-12-28
最終更新日	2024-07-17
実験手法	ELECTRON MICROSCOPY (2.58 Å)
主引用文献	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

7R0E

Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position
分子名称:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者	Cusack, S, Kouba, T.
登録日	2022-02-01
公開日	2022-12-28
最終更新日	2024-07-17
実験手法	ELECTRON MICROSCOPY (2.51 Å)
主引用文献	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

8BE0

Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the C +1 position
分子名称:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者	Cusack, S, Kouba, T.
登録日	2022-10-20
公開日	2022-12-28
最終更新日	2024-07-24
実験手法	ELECTRON MICROSCOPY (2.34 Å)
主引用文献	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

8BDR

Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the U +1 position
分子名称:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者	Cusack, S, Kouba, T.
登録日	2022-10-19
公開日	2022-12-28
最終更新日	2024-07-24
実験手法	ELECTRON MICROSCOPY (2.7 Å)
主引用文献	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

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