5J5X

Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1416

Summary for 5J5X

• Entry DOI: 10.2210/pdb5j5x/pdb
• Related: 5IZF 5IZJ
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, 47P-AZ1-DAL-DAR-DAR-DAR-DAR, SULFATE ION, ... (5 entities in total)
• Functional Keywords: protein kinase, inhibitor, bisubstrate, oligoarginine, pka, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 42357.33

Authors

Alam, K.A.,Ivan, T.,Uri, A.,Engh, R.A. (deposition date: 2016-04-04, release date: 2016-07-20, Last modification date: 2019-06-19)

• Primary citation: Ivan, T.,Enkvist, E.,Viira, B.,Manoharan, G.B.,Raidaru, G.,Pflug, A.,Alam, K.A.,Zaccolo, M.,Engh, R.A.,Uri, A.; Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions.; Bioconjug.Chem., 27:1900-1910, 2016; PubMed: 27389935; DOI: 10.1021/acs.bioconjchem.6b00293

Experimental method

X-RAY DIFFRACTION (2.6 Å)