6EUY

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor

Summary for 6EUY

• Entry DOI: 10.2210/pdb6euy/pdb
• Descriptor: Polymerase basic protein 2, (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, SULFATE ION (3 entities in total)
• Functional Keywords: influenza a polymerase pb2 subunit cap-binding domain cap-binding inhibitor, rna binding protein
• Biological source: Influenza A virus (A/Victoria/3/1975(H3N2))
• Cellular location: Virion : P31345
• Total number of polymer chains: 3
• Total formula weight: 99350.49

Authors

Cusack, S.,Gaudon, S. (deposition date: 2017-10-31, release date: 2017-12-13, Last modification date: 2024-01-17)

• Primary citation: Pflug, A.,Gaudon, S.,Resa-Infante, P.,Lethier, M.,Reich, S.,Schulze, W.M.,Cusack, S.; Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.; Nucleic Acids Res., 46:956-971, 2018; PubMed: 29202182; DOI: 10.1093/nar/gkx1210

Experimental method

X-RAY DIFFRACTION (3 Å)