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7AW2

MerTK kinase domain with type 1.5 inhibitor from a DNA-encoded library

Summary for 7AW2
Entry DOI10.2210/pdb7aw2/pdb
DescriptorTyrosine-protein kinase Mer, 5-(2'-chloro-[1,1'-biphenyl]-4-yl)-N-(imidazo[1,2-a]pyridin-6-ylmethyl)-N-methyl-1,3,4-oxadiazol-2-amine (3 entities in total)
Functional Keywordstyrosine kinase, inhibitor, type1.5 kinase inhibitor, structure-based drug design, dna-encoded library, oncology, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight34797.63
Authors
Primary citationNissink, J.W.M.,Bazzaz, S.,Blackett, C.,Clark, M.A.,Collingwood, O.,Disch, J.S.,Gikunju, D.,Goldberg, K.,Guilinger, J.P.,Hardaker, E.,Hennessy, E.J.,Jetson, R.,Keefe, A.D.,McCoull, W.,McMurray, L.,Olszewski, A.,Overman, R.,Pflug, A.,Preston, M.,Rawlins, P.B.,Rivers, E.,Schimpl, M.,Smith, P.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J.,Woodcock, S.,Zhang, Y.
Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.
J.Med.Chem., 64:3165-3184, 2021
Cited by
PubMed: 33683117
DOI: 10.1021/acs.jmedchem.0c01904
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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