7R1F
Early transcription elongation state of influenza B polymerase backtracked due to double incoproation of nucleotide analogue T1106
Summary for 7R1F
Entry DOI | 10.2210/pdb7r1f/pdb |
Related | 7QTL |
EMDB information | 14240 |
Descriptor | Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ... (9 entities in total) |
Functional Keywords | influenza, viral rna-dependent rna polymerase; antiviral drug; nucleoside analogue; t705 (favipiravir); t1106; cap-dependent transcription; backtracking;, viral protein |
Biological source | Influenza B virus (B/Memphis/13/2003) More |
Total number of polymer chains | 6 |
Total formula weight | 281280.85 |
Authors | Cusack, S.,Kouba, T. (deposition date: 2022-02-02, release date: 2022-12-28, Last modification date: 2023-02-15) |
Primary citation | Kouba, T.,Dubankova, A.,Drncova, P.,Donati, E.,Vidossich, P.,Speranzini, V.,Pflug, A.,Huchting, J.,Meier, C.,De Vivo, M.,Cusack, S. Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42:111901-111901, 2023 Cited by PubMed: 36596301DOI: 10.1016/j.celrep.2022.111901 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.58 Å) |
Structure validation
Download full validation report