8BDR

Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the U +1 position

Summary for 8BDR

Entry DOI	10.2210/pdb8bdr/pdb
Related	7QTL
EMDB information	15984
Descriptor	Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ... (8 entities in total)
Functional Keywords	influenza, viral rna-dependent rna polymerase; antiviral drug; nucleoside analogue; t705 (favipiravir); t1106; cap-dependent transcription; backtracking;, viral protein
Biological source	Influenza B virus (B/Memphis/13/2003) More
Total number of polymer chains	6
Total formula weight	280880.27
Authors	Cusack, S.,Kouba, T. (deposition date: 2022-10-19, release date: 2022-12-28, Last modification date: 2023-02-15)
Primary citation	Kouba, T.,Dubankova, A.,Drncova, P.,Donati, E.,Vidossich, P.,Speranzini, V.,Pflug, A.,Huchting, J.,Meier, C.,De Vivo, M.,Cusack, S. Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42:111901-111901, 2023 Cited by PubMed: 36596301 DOI: 10.1016/j.celrep.2022.111901 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.7 Å)

Structure validation